A facile synthesis of novel pyrrolo[3,4-b]quinolin-1-one derivatives

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• 作者：Kai Li ; Xinbo Fu ; Yanan Zhao ; Wentao Gao ; Yang Li
• 关键词：Quinoline ; Isoindolin ; l ; one ; Hybrid ; One ; pot synthesis ; Amine
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：42
• 期：5
• 页码：4273-4287
• 全文大小：1,362 KB
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• 作者单位：Kai Li (1)
  Xinbo Fu (1)
  Yanan Zhao (1)
  Wentao Gao (1)
  Yang Li (1)
  
  1. Institute of Superfine Chemicals, Bohai University, Jinzhou, 121000, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

A simple and concise construction of a series of new quinoline-based isoindolin-l-ones, namely N-substituted-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones, wherein the benzene moiety of isoindolin-l-one is replaced by a quinoline ring has been achieved via a two-step procedure, involving the one-step synthesis of ethyl 2-chloromethyl-quinoline-3-carboxylate followed by its one-pot reaction with various amines in a refluxing EtOH–AcOH (v/v, 10:1) solvent system. These newly synthesized compounds could be good candidates for the development of lead compounds for use in medicinal chemistry.