Roles of connexins and pannexins in digestive homeostasis

详细信息    查看全文

• 作者：Micha?l Maes ; Bruno Cogliati ; Sara Crespo Yanguas…
• 关键词：Stomach ; Intestine ; Liver ; Pannexin ; Connexin ; Physiology
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：72
• 期：15
• 页码：2809-2821
• 全文大小：730 KB
• 参考文献：1.Alexander DB, Goldberg GS (2003) Transfer of biologically important molecules between cells through gap junction channels. Curr Med Chem 10(19):2045-058PubMed
  2.Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS (2009) Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal 7:4. doi:10.-186/-478-811X-7-4 PubMed Central PubMed
  3.Decrock E, Vinken M, De Vuyst E, Krysko DV, D’Herde K, Vanhaecke T, Vandenabeele P, Rogiers V, Leybaert L (2009) Connexin-related signaling in cell death: to live or let die? Cell Death Differ 16(4):524-36. doi:10.-038/?cdd.-008.-96 PubMed
  4.Loewenstein WR, Kanno Y (1967) Intercellular communication and tissue growth I. Cancerous growth. J Cell Biol 33(2):225-34PubMed Central PubMed
  5.Revel JP, Karnovsky MJ (1967) Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J Cell Biol 33(3):C7–C12PubMed Central PubMed
  6.Goodenough DA (1974) Bulk isolation of mouse hepatocyte gap junctions. Characterization of the principal protein, connexin. J Cell Biol 61(2):557-63PubMed Central PubMed
  7.Paul DL (1986) Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol 103(1):123-34PubMed
  8.Kumar NM, Gilula NB (1986) Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein. J Cell Biol 103(3):767-76PubMed
  9.Bai D, Wang AH (2014) Extracellular domains play different roles in gap junction formation and docking compatibility. Biochem J 458(1):1-0. doi:10.-042/?BJ20131162 PubMed
  10.Li Z, Zhou Z, Daniel EE (1993) Expression of gap junction connexin 43 and connexin 43 mRNA in different regional tissues of intestine in dog. Am J Physiol 265(5):G911–G916PubMed
  11.Mikkelsen HB, Huizinga JD, Thuneberg L, Rumessen JJ (1993) Immunohistochemical localization of a gap junction protein (connexin43) in the muscularis externa of murine, canine, and human intestine. Cell Tissue Res 274(2):249-56PubMed
  12.Panchin Y, Kelmanson I, Matz M, Lukyanov K, Usman N, Lukyanov S (2000) A ubiquitous family of putative gap junction molecules. Curr Biol 10(13):R473–R474PubMed
  13.Wang N, De Bock M, Decrock E, Bol M, Gadicherla A, Vinken M, Rogiers V, Bukauskas FF, Bultynck G, Leybaert L (2013) Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta 1828(1):35-0. doi:10.-016/?j.?bbamem.-012.-7.-02 PubMed Central PubMed
  14.Diezmos EF, Sandow SL, Markus I, Shevy Perera D, Lubowski DZ, King DW, Bertrand PP, Liu L (2013) Expression and localization of pannexin-1 hemichannels in human colon in health and disease. Neurogastroenterol Motil 25(6):e395–e405. doi:10.-111/?nmo.-2130 PubMed
  15.Le Vasseur M, Lelowski J, Bechberger JF, Sin WC, Naus CC (2014) Pannexin 2 protein expression is not restricted to the CNS. Front Cell Neurosci 8:392. doi:10.-389/?fncel.-014.-0392 PubMed Central PubMed
  16.Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (2003) Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA 100(23):13644-3649PubMed Central PubMed
  17.Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G (2011) Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology 54(1):133-44. doi:10.-002/?hep.-4341 PubMed Central PubMed
  18.Ganz M, Csak T, Nath B, Szabo G (2011) Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver. World J Gastroenterol 17(43):4772-778. doi:10.-748/?wjg.?v17.?i43.-772 PubMed Central PubMed
  19.Kim HY, Kim SJ, Lee SM (2015) Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion. FEBS J 282(2):259-70. doi:10.-111/?febs.-3123 PubMed
  20.Xiao F, Waldrop SL, Khimji AK, Kilic G (2012) Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells. Am J Physiol Cell Physiol 303(10):C1034–C1044. doi:10.-152/?ajpcell.-0175.-012 PubMed Central PubMed
  21.Li X, Cao J, Jin Q, Xie C, He Q, Cao R, Xiong J, Chen P, Wang X, Liang S (2008) A proteomic study reveals the diversified distribution of plasma membrane-associated proteins in rat hepatocytes. J Cell Biochem 104(3):965-84. doi:10.-002/?jcb.-1680 PubMed
  22.Sáez PJ, Shoji KF, Aguirre A, Sáez JC (2014) Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells. Mediators Inflamm 2014:742734. doi:10.-155/-014/-42734 PubMed Central PubMed
  23.Chandrasekhar A, Bera AK (2012) Hemichannels: permeants and their effect on development, physiology and death. Cell Biochem Funct 30(2):89-00PubMed
  24.Spray DC, Ye ZC, Ransom BR (2006) Functional connexin “hemichannels- a critical appraisal. Glia 54(7):758-73PubMed
  25.Harris AL (2007) Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol 94(1-):120-43. doi:10.-016/?j.?pbiomol
• 作者单位：Micha?l Maes (1)
  Bruno Cogliati (2)
  Sara Crespo Yanguas (1)
  Joost Willebrords (1)
  Mathieu Vinken (1)
  
  1. Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium
  2. Department of Pathology, School of Veterinary Medicine and Animal Science, University of S?o Paulo, S?o Paulo, Brazil
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate immune defense, xenobiotic biotransformation, glycogenolysis, bile secretion, ammonia detoxification and plasma protein synthesis. In the last decade, it has become clear that connexin hemichannels, which are the structural precursors of gap junctions, also provide a pathway for cellular communication, namely between the cytosol and the extracellular environment. Although merely pathological functions have been described, some physiological roles have been attributed to connexin hemichannels, in particular in the modulation of colonic motility. This equally holds true for cellular channels composed of pannexins, connexin-like proteins recently identified in the intestine and the liver, which have become acknowledged key players in inflammatory processes and that have been proposed to control colonic motility, secretion and blood flow.