Experimental models of liver fibrosis

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• 作者：Sara Crespo Yanguas ; Bruno Cogliati ; Joost Willebrords…
• 刊名：Archives of Toxicology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：90
• 期：5
• 页码：1025-1048
• 全文大小：2,258 KB
• 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0738
• 卷排序：90

文摘

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, chronic hepatitis virus infection and non-alcoholic steatohepatitis. A central event in liver fibrosis is the activation of hepatic stellate cells, which is triggered by a plethora of signaling pathways. Liver fibrosis can progress into more severe stages, known as cirrhosis, when liver acini are substituted by nodules, and further to hepatocellular carcinoma. Considerable efforts are currently devoted to liver fibrosis research, not only with the goal of further elucidating the molecular mechanisms that drive this disease, but equally in view of establishing effective diagnostic and therapeutic strategies. The present paper provides a state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research.KeywordsLiver fibrosisAnimal modelsIn vitro modelsHepatic stellate cells