Genetic variations in the homologous recombination repair pathway genes modify risk of glioma

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• 作者：Haishi Zhang ; Yanhong Liu ; Keke Zhou ; Chengcheng Zhou…
• 关键词：Glioma ; Homologous recombination pathway ; Functional polymorphism ; Susceptibility
• 刊名：Journal of Neuro-Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：126
• 期：1
• 页码：11-17
• 全文大小：369 KB
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• 作者单位：Haishi Zhang (1)
  Yanhong Liu (2)
  Keke Zhou (1)
  Chengcheng Zhou (1)
  Renke Zhou (2)
  Chunxia Cheng (2) (3)
  Qingyi Wei (4)
  Daru Lu (5)
  Liangfu Zhou (1) (6)
  
  1. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200433, China
  2. Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA
  3. Department of Obstetrics聽and聽Gynecology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China
  4. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, 27710, USA
  5. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, No. 220 Handan Road, Shanghai, 200433, China
  6. Department of Neurosurgery, Huashan Hospital, Fudan University, 12 Wulumuqi Road, Shanghai, 200040, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Accumulative epidemiological evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in homologous recombination (HR) DNA repair pathway play an important role in glioma susceptibility. However, the effects of such SNPs on glioma risk remain unclear. We used a used a candidate pathway-based approach to elucidate the relationship between glioma risk and 12 putative functional SNPs in genes involved in the HR pathway. Genotyping was conducted on 771 histologically-confirmed glioma patients and 752 cancer-free controls from the Chinese Han population. Odds ratios (OR) were calculated both for each SNP individually and for grouped analyses, examining the effects of the numbers of adverse alleles on glioma risk, and evaluated their potential gene鈥揼ene interactions using the multifactor dimensionality reduction (MDR). In the single-locus analysis, two variants, the NBS1 rs1805794 (OR 1.42, 95 % CI 1.15鈥?.76, P = 0.001), and RAD54L rs1048771 (OR 1.61, 95 % CI 1.17鈥?.22, P = 0.002) were significantly associated with glioma risk. When we examined the joint effects of the risk-conferring alleles of these three SNPs, we found a significant trend indicating that the risk increases as the number of adverse alleles increase (P = 0.005). Moreover, the MDR analysis suggested a significant three-locus interaction model involving NBS1 rs1805794, MRE11 rs10831234, and ATM rs227062. These results suggested that these variants of the genes involved in the HR pathway may contribute to glioma susceptibility. Keywords Glioma Homologous recombination pathway Functional polymorphism Susceptibility