Prolonged mechanical ventilation–induced neuroinflammation affects postoperative memory dysfunction in surgical mice

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• 作者：Chang Chen ; Zongze Zhang ; Ting Chen ; Mian Peng ; Xing Xu ; Yanlin Wang
• 刊名：Critical Care
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：19
• 期：1
• 全文大小：3,296 KB
• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Introduction Patients undergoing surgery frequently develop neuropsychological disturbances, including cognitive decline or memory impairment, and routine clinical procedures such as mechanical ventilation (MV) may affect acute-phase brain outcome. We aimed to investigate the effect of the prolonged MV on postoperative memory dysfunction in surgical mice.