KSHV strategies for host dsDNA sensing machinery
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- 作者：Hang Gao ; Yanyan Song ; Chengrong Liu ; Qiming Liang
- 关键词：Kaposi’s sarcoma ; associated herpesvirus (KSHV) ; innate immune response ; cyclic GMP ; AMP synthase (cGAS) ; interferon ; autophagy ; evasion strategies
- 刊名：Virologica Sinica
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：31
- 期：6
- 页码：466-471
- 全文大小：
- 刊物主题：Virology; Medical Microbiology; Oncology; Biochemistry, general; Microbiology; Microbial Genetics and Genomics;
- 出版者：Springer Singapore
- ISSN：1995-820X
- 卷排序：31
文摘
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi’s Sarcoma-associated Herpesvirus (KSHV) and their contributions to KSHV life cycles.KeywordsKaposi’s sarcoma-associated herpesvirus (KSHV)innate immune responsecyclic GMP-AMP synthase (cGAS)interferonautophagyevasion strategiesORCID: 0000-0003-4792-1547