Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

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• 作者：Hee-jin Jun (1)
  Minh-Hien Hoang (1)
  Jin Woo Lee (3)
  Jia Yaoyao (1)
  Ji-Hae Lee (1)
  Dong-Ho Lee (1)
  Hak-Ju Lee (2)
  Woo-Duck Seo (3)
  Bang Yeon Hwang (4)
  Sung-Joon Lee (1)
  
• 关键词：Belamcanda chinensis ; Cholesterol ; Iristectorigenin B ; LXR modulator
• 刊名：Biotechnology Letters
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：34
• 期：12
• 页码：2213-2221
• 全文大小：568KB
• 参考文献：1. Albers M, Blume B, Schlueter T, Wright MB, Kober I, Kremoser C, Deuschle U, Koegl M (2006) A novel principle for partial agonism of liver X receptor ligands—Competitive recruitment of activators and repressors. J Biol Chem 281(8):4920-930 CrossRef
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• 作者单位：Hee-jin Jun (1)
  Minh-Hien Hoang (1)
  Jin Woo Lee (3)
  Jia Yaoyao (1)
  Ji-Hae Lee (1)
  Dong-Ho Lee (1)
  Hak-Ju Lee (2)
  Woo-Duck Seo (3)
  Bang Yeon Hwang (4)
  Sung-Joon Lee (1)
  
  1. Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, South Korea
  3. Department of Functional Crop, National Institute of Crop Science, Miryang, 627-803, South Korea
  2. Division of Green Business Management, Department of Forest Resources Utilization, Korean Forest Research Institute, Seoul, 130-712, South Korea
  4. College of Pharmacy, Chungbuk National University, Cheongju, 361-763, South Korea
  
• ISSN：1573-6776

文摘

A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.