Impact of non-di-(2-ethylhexyl)phthalate cardiopulmonary bypass tubes on inflammatory cytokines and coagulation-fibrinolysis systems during cardiopulmonary bypass

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• 作者：Yosuke Takahashi ; Toshihiko Shibata ; Yasuyuki Sasaki ; Hiromichi Fujii ; Takeshi Ikuta ; Yasuyuki Bito ; Atsushi Nakahira and Shigefumi Suehiro
• 关键词：Di ; (2 ; ethylhexyl)phthalate (DEHP) ; CABG ; CPB ; Inflammatory response
• 刊名：Journal of Artificial Organs
• 出版年：2009
• 出版时间：December, 2009
• 年：2009
• 卷：12
• 期：4
• 页码：226-231
• 全文大小：296.1 KB

文摘

Di-(2-ethylhexyl)phthalate (DEHP), an excellent plasticizer for poly(vinyl chloride) (PVC), is a known endocrine-disrupting chemical. This study was designed to investigate whether a new non-DEHP bilayer tube reduced the release of DEHP, suppressed inflammatory cytokines, and altered coagulation-fibrinolysis systems. Sixteen patients undergoing coronary artery bypass grafting (CABG) were randomly assigned to the non-DEHP bilayer group (group B, n = 8), or the noncoated PVC group (group N, n = 8). The level of DEHP in the blood was measured before and after cardiopulmonary bypass (CPB). The levels of interleukin-6 (IL-6), D-dimer, and thrombin-antithrombin complex (TAT) were also measured at six points during and after CPB. DEHP was significantly lower in group B (472 ¡À 141 ng/ml) after CPB compared with group N (2094 ¡À 1046 ng/ml). The IL-6 level was significantly lower in group B (151 ¡À 131 pg/ml) than group N (206 ¡À 224 pg/ml) 180 min after protamine administration. The D-dimer level was significantly lower in group B 60 min after protamine administration (6.2 ¡À 2.4 μg/ml in group B vs 10.4 ¡À 4.5 μg/ml in group N) and 180 min after protamine administration (4.4 ¡À 0.7 μg/ml in group B vs 7.3 ¡À 2.7 μg/ml in group N). Group B had a tendency toward reduced postoperative bleeding compared with group N at any time. The bilayer tube was superior to the noncoated tube in terms of the inhibition of DEHP release, inflammatory cytokines, and the fibrinolysis system.