Sevoflurane does not alter norepinephrine-induced intracellular Ca2+ changes in the diabetic rat aorta
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- 作者：Keisuke Fujii MD (1)
Koji Ogawa MD (2)
Yasuyuki Tokinaga MD (2)
Hiroshi Iranami MD (1)
Yoshio Hatano MD (2) - 刊名：Canadian Journal of Anesthesia/Journal canadien d'anesth篓娄sie
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：57
- 期：12
- 页码：1095-1101
- 全文大小：379KB
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Koji Ogawa MD (2)
Yasuyuki Tokinaga MD (2)
Hiroshi Iranami MD (1)
Yoshio Hatano MD (2)
1. Departments of Anesthesiology, Japanese Red Cross Society Wakayama Medical Centre, Wakayama, Japan
2. Wakayama Medical University, Wakayama, Japan
文摘
Purpose The effect of volatile anesthetics on the mechanism(s) of vascular contraction in diabetes mellitus (DM) has not been fully understood. The current study was designed to determine the effects of sevoflurane on the norepinephrine (NE)-induced changes in contractile state and intracellular Ca2+ concentrations ([Ca2+]i) in the spontaneously developing type 2 DM rat. Methods The effects of sevoflurane on NE (10?M)-induced vasoconstriction and increase in [Ca2+]i in the aortas from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 DM model, and from age-matched control Long-Evans Tokushima Otsuka (LETO) rats were investigated using an isometric force transducer and fluorometer with fura-2 as an indicator of [Ca2+]i. Results Norepinephrine-induced increases in tension and [Ca2+]i in?OLETF?rats?were 54.8%, 95% confidence interval (CI) 36.9-72.6% and 58.8%, 95% CI 51.5-66.1%, respectively, and in LETO rats they were 46.4%, 95% CI 39.0-53.7% and 53.8%, 95% CI 46.9-60.7%, respectively,?when?expressed as the percentage relative to that induced by KCl 30?mM. In LETO rats, sevoflurane at a concentration of 3.4% inhibited the vascular contraction (9.4%, 95% CI 6.3-12.6%; P?<?0.001) and the increase in [Ca2+]i (33.3%, 95% CI 27.4-39.2%; P?=?0.002). In OLETF rats, however, sevoflurane failed to affect either the NE-induced contraction (43.6%, 95% CI 28.3-58.9%; P?=?0.68) or the elevation in [Ca2+]i (60.5%, 95% CI 56.3-64.8%; P?=?0.93). Conclusion Sevoflurane at clinically relevant concentrations inhibited the NE-induced increase in [Ca2+]i in the aortic smooth muscle from normal rats but not in that from type 2 DM rats. Thus, a Ca2+- signalling pathway resistant to sevoflurane appears to exist in the type 2 DM rat aorta.