Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride

详细信息    查看全文

• 作者：Fumitoshi Kodaka (1) (3)
  Hiroshi Ito (1) (2)
  Yasuyuki Kimura (1)
  Saori Fujie (1)
  Harumasa Takano (1)
  Hironobu Fujiwara (1)
  Takeshi Sasaki (1)
  Kazuhiko Nakayama (3)
  Christer Halldin (4)
  Lars Farde (4)
  Tetsuya Suhara (1)
  
• 关键词：[11C]MNPA ; [11C]Raclopride ; Dopamine D2/3 receptor ; High ; affinity state ; Test ; retest reproducibility
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：40
• 期：4
• 页码：574-579
• 全文大小：191KB
• 参考文献：1. De Lean A, Kilpatrick BF, Caron MG. Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists. Mol Pharmacol 1982;22:290-.
  2. Seeman P, Tallerico T, Ko F, Tenn C, Kapur S. Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges. Synapse 2002;46:235-. CrossRef
  3. Seneca N, Finnema SJ, Farde L, Gulyás B, Wikstr?m HV, Halldin C, et al. Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride. Synapse 2006;59:260-. CrossRef
  4. Gao YG, Baldessarini RJ, Kula NS, Neumeyer JL. Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem 1990;33:1800-. CrossRef
  5. Seeman P, Wilson A, Gmeiner P, Kapur S. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse 2006;60:205-1. CrossRef
  6. Skinbjerg M, Namkung Y, Halldin C, Innis RB, Sibley DR. Pharmacological characterization of 2-methoxy-N-propylnorapomorphine’s interactions with D2 and D3 dopamine receptors. Synapse 2009;63:462-5. CrossRef
  7. Searle G, Beaver JD, Comley RA, Bani M, Tziortzi A, Slifstein M, et al. Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist. Biol Psychiatry 2010;68:392-. CrossRef
  8. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996;4:153-. CrossRef
  9. Fleiss J. The design and analysis of clinical experiments. New York: Wiley; 1986.
  10. Hirvonen J, Aalto S, Lumme V, N?gren K, Kajander J, Vilkman H, et al. Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride. Nucl Med Commun 2003;24:1207-4. CrossRef
  11. Otsuka T, Ito H, Halldin C, Takahashi H, Takano H, Arakawa R, et al. Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain. J Nucl Med 2009;50:703-0. CrossRef
  
• 作者单位：Fumitoshi Kodaka (1) (3)
  Hiroshi Ito (1) (2)
  Yasuyuki Kimura (1)
  Saori Fujie (1)
  Harumasa Takano (1)
  Hironobu Fujiwara (1)
  Takeshi Sasaki (1)
  Kazuhiko Nakayama (3)
  Christer Halldin (4)
  Lars Farde (4)
  Tetsuya Suhara (1)
  
  1. Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
  3. Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
  2. Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan
  4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
  
• ISSN：1619-7089

文摘

Purpose Dopamine D2/3 receptors (D2/3Rs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D2/3 HIGH), which has a high affinity for endogenous dopamine, and low-affinity state (D2/3 LOW). The density of D2/3 HIGH can be measured with (R)-2-11CH3O-N-n-propylnorapomorphine ([11C]MNPA), while total density of D2/3 HIGH and D2/3 LOW (D2/3Rs) can be measured with [11C]raclopride using positron emission tomography (PET). Thus, the ratio of the binding potential (BP) of [11C]MNPA to that of [11C]raclopride ([11C]MNPA/[11C]raclopride) may reflect the proportion of the density of D2/3 HIGH to that of D2/3Rs. In the caudate and putamen, [11C]MNPA/[11C]raclopride reflects the proportion of the density of D2 HIGH to that of D2Rs. To evaluate the reliability of the PET paradigm with [11C]MNPA and [11C]raclopride, we investigated the test-retest reproducibility of non-displaceable BP (BP ND) measured with [11C]MNPA and of [11C]MNPA/[11C]raclopride in healthy humans. Methods Eleven healthy male volunteers underwent two sets of PET studies on separate days that each included [11C]MNPA and [11C]raclopride scans. BP ND values in the caudate and putamen were calculated. Test-retest reproducibility of BP ND of [11C]MNPA and [11C]MNPA/[11C]raclopride was assessed by intra-subject variability (absolute variability) and test-retest reliability (intraclass correlation coefficient: ICC). Results The absolute variability of [11C]MNPA BP ND was 5.30?±-.96?% and 12.3?±-.95?% and the ICC values of [11C]MNPA BP ND were 0.72 and 0.82 in the caudate and putamen, respectively. The absolute variability of [11C]MNPA/[11C]raclopride was 6.11?±-.68?% and 11.60?±-.70?% and the ICC values of [11C]MNPA/[11C]raclopride were 0.79 and 0.80 in the caudate and putamen, respectively. Conclusion In the present preliminary study, the test-retest reproducibility of BP ND of [11C]MNPA and of [11C]MNPA/[11C]raclopride was reliable in the caudate and putamen.