Serum concentration of lidocaine after transversus abdominis plane block
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- 作者：Naoko Kato ; Yoshihiro Fujiwara ; Misako Harato ; Shuji Kurokawa ; Yasuyuki Shibata ; Jun Harada and Toru Komatsu
- 关键词：Transversus abdominis plane block ; Lidocaine ; Serum concentration
- 刊名：Journal of Anesthesia
- 出版年：2009
- 出版时间：May, 2009
- 年：2009
- 卷：23
- 期：2
- 页码：298-300
- 全文大小：117.8 KB
文摘
We measured the serum concentration of lidocaine after transversus abdominis plane (TAP) block with 40 ml of 1 % lidocaine in 12 patients under general anesthesia, using a fluorescence polarization immunoassay. The peak mean serum concentration of lidocaine occurred 30 min after the block (3.6 ¡À 0.7 μg¡¤ml−1). The highest concentration of lidocaine (5.5 μg¡¤ml−1) was recorded 15 min after the block. These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially depend on the rise in serum concentration of the local anesthetic.