Paradigm change to cost-effective predictive and preventive medicine: individual profiling of healthy vasospastic individuals for targeted prevention as the cost-effective personalised medicine
参考文献:1. Mozaffarieh M, Fraenkl S, Konieczka K, Flammer J: Targeted preventive measures and advanced approaches in personalised treatment of glaucoma neuropathy. / EPMA J 2010, 1:229鈥?36. CrossRef 2. Flammer J, Pache M, Resink T: Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. / Prog Retin Eye Res 2001, 20:319鈥?49. CrossRef 3. Yeghiazaryan K, Flammer J, Org眉l S, Wunderlich K, Golubnitschaja O: Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes. / Mol Vis 2009, 15:2339鈥?348. 4. Golubnitschaja O, Yeghiazaryan K, Wunderlich K, Schild HH, Flammer J: Disease proteomics reveals altered basic gene expression regulation in leukocytes of glaucoma patients. / Proteomics Clin Appl 2007, 1:1316鈥?323. CrossRef 5. Yeghiazaryan K, Flammer J, Golubnitschaja O: Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of 鈥渄own-stream鈥?pathologies as the cost-effective personalised medicine. In / Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future. Edited by: Mandel S. Book series: Advances in PPPM, Springer; 2013.
作者单位:Olga Golubnitschaja (307) Kristina Yeghiazaryan (307) Josef Flammer (308)
307. Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Kragujevac, Germany 308. Department of Ophthalmology, University Hospital Basel, Kragujevac, Switzerland