Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?

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• 作者：Olga Golubnitschaja (1) (2)
  Kristina Yeghiazaryan (1) (2)
  Vincenzo Costigliola (3)
  Daniela Trog (1) (2)
  Michael Braun (2) (4) (5)
  Manuel Debald (2) (4)
  Walther Kuhn (2) (4)
  Hans H Schild (1) (2)
  
• 关键词：Inflammation ; Cancer ; Metastasis ; Biomarker pattern ; Predictive diagnosis ; Preventive healthcare ; Medical services ; Medical record ; Integrative personalised medicine ; Innovative technologies ; Genetic testing ; Assay ; Omics ; Imaging ; Immune system ; Metalloproteinase ; Adjuvant therapy ; Computer assistance ; Mathematical modelling ; Tamoxifen ; Ethics
• 刊名：The EPMA Journal
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：4
• 期：1
• 全文大小：684KB
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• 作者单位：Olga Golubnitschaja (1) (2)
  Kristina Yeghiazaryan (1) (2)
  Vincenzo Costigliola (3)
  Daniela Trog (1) (2)
  Michael Braun (2) (4) (5)
  Manuel Debald (2) (4)
  Walther Kuhn (2) (4)
  Hans H Schild (1) (2)
  
  1. Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, Bonn, 53105, Germany
  2. Breast Cancer Research Centre, University of Bonn, Bonn, Germany
  3. European Medical Association, Brussels, Belgium
  4. Department of Obstetrics and Gynaecology, University of Bonn, Bonn, Germany
  5. Department of Gynaecology, Red Cross Clinics Munich, Munich, Germany
  

文摘

Breast cancer is a multifactorial disease. A spectrum of internal and external factors contributes to the disease promotion such as a genetic predisposition, chronic inflammatory processes, exposure to toxic compounds, abundant stress factors, a shift-worker job, etc. The cumulative effects lead to high incidence of breast cancer in populations worldwide. Breast cancer in the USA is currently registered with the highest incidence rates amongst all cancer related patient cohorts. Currently applied diagnostic approaches are frequently unable to recognise early stages in tumour development that impairs individual outcomes. Early diagnosis has been demonstrated to be highly beneficial for significantly enhanced therapy efficacy and possibly full recovery. Actual paper shows that the elaboration of an integrative diagnostic approach combining several levels of examinations creates a robust platform for the reliable risk assessment, targeted preventive measures and more effective treatments tailored to the person in the overall task of breast cancer management. The levels of examinations are proposed, and innovative technological approaches are described in the paper. The absolute necessity to create individual patient profiles and extended medical records is justified for the utilising by routine medical services. Expert recommendations are provided to promote further developments in the field.