Formation of Peptide Radical Cations (M+·) in Electron Capture Dissociation of Peptides Adducted with Group IIB Metal Ions
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- 作者：Xiangfeng Chen (1)
Wai Yi Kelly Chan (1)
Pui Shuen Wong (1)
Hoi Sze Yeung (1)
Tak Wah Dominic Chan (1) - 关键词：Electron capture dissociation ; Peptides ; Group IIB transition metal ions ; Electron transfer
- 刊名：Journal of The American Society for Mass Spectrometry
- 出版年：2011
- 出版时间：February 2011
- 年：2011
- 卷：22
- 期：2
- 页码：233-244
- 全文大小：387KB
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Wai Yi Kelly Chan (1)
Pui Shuen Wong (1)
Hoi Sze Yeung (1)
Tak Wah Dominic Chan (1)
1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, SAR, China
文摘
Peptides adducted with different divalent Group IIB metal ions (Zn2+, Cd2+, and Hg2+) were found to give very different ECD mass spectra. ECD of Zn2+ adducted peptides gave series of c-/z-type fragment ions with and without metal ions. ECD of Cd2+ and Hg2+ adducted model peptides gave mostly a-type fragment ions with M+-/sup> and fragment ions corresponding to losses of neutral side chain from M+-/sup>. No detectable a-ions could be observed in ECD spectra of Zn2+ adducted peptides. We rationalized the present findings by invoking both proton-electron recombination and metal-ion reduction processes. As previously postulated, divalent metal-ions adducted peptides could adopt several forms, including (a) [M + Cat]2+, (b) [(M + Cat -H) + H]2+, and (c) [(M + Cat -2H) + 2H]2+. The relative population of these precursor ions depends largely on the acidity of the metal–ion peptide complexes. Peptides adducted with divalent metal-ions of small ionic radii (i.e., Zn2+) would form predominantly species (b) and (c); whereas peptides adducted with metal ions of larger ionic radii (i.e., Hg2+) would adopt predominantly species (a). Species (b) and (c) are believed to be essential for proton-electron recombination process to give c-/z-type fragments via the labile ketylamino radical intermediates. Species (c) is particularly important for the formation of non-metalated c-/z-type fragments. Without any mobile protons, species (a) are believed to undergo metal ion reduction and subsequently induce spontaneous electron transfer from the peptide moiety to the charge-reduced metal ions. Depending on the exothermicity of the electron transfer reaction, the peptide radical cations might be formed with substantial internal energy and might undergo further dissociation to give structural related fragment ions.