Chromosomal Mapping of a Skeletal Muscle Specific LIM-Only Protein FHL3 to the Distal End of the Short Arm of Human Chromosome 1

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• 作者：Simon Ming Yuen Lee ; Stephen Kwok Wing Tsui ; Kwok Keung Chan ; Masayo Kotaka ; Hoi Yeung Li ; Stephen Siu Chung Chim ; Mary Miu Yee Waye ; Kwok Pui Fung and Cheuk Yu Lee
• 刊名：Somatic Cell and Molecular Genetics
• 出版年：1998
• 出版时间：1998
• 年：1998
• 卷：24
• 期：3
• 页码：197-202
• 全文大小：1.28 MB

文摘

Four-and-a-halfLIM domain proteins (FHL) possess four tandem repeats of LIM domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mapping of skeletal muscle LIM protein FHL3 were reported. When the FHL3 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal could be detected in heart, brain, placenta, lung, liver, kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies.