Dependablity study on near-infrared parameters of blood oxygen and microvessel density of mammary gland phyma

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• 作者：Ye Huang (1)
  Dengfeng Chen (1)
  Lu Yuan (1)
  Yian Liu (1)
  Hua Liu (1)
  Liu Zhang (1)
  Jun Kong (1)
  Hong Wang (1)
  
• 关键词：mammary gland phyma ; microvessel density ; near ; infrared parameters of blood oxygen
• 刊名：The Chinese-German Journal of Clinical Oncology
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：6
• 期：4
• 页码：365-368
• 全文大小：251KB
• 参考文献：1. Xie ZP, Wang XF, Zhang XL, / et al. Clinical study on diagnosis of breast cancer by non-invasive near-infrared detector. Chin J Cancer (Chinese), 2000, 19: 185.
  2. Ji XL, Shi ZL. Diagnostic immunohistochemistry. Beijing: Military Medical Science Press, 1997. 19-1.
  3. Li X, Beauvoit B, White R, / et al. Tumor localization using fluorescence of indocyanine green (ICG) in rat models. SPIE, 1995, 2389: 789-97. CrossRef
  4. Nioka S, Yang Y, Shnall M, / et al. Optical imaging of breast tumor by means of continuous waves. Adv Exp Med Biol, 1997, 411: 227-32.
  5. Hawrysz DJ, Sevick-Muraca EM. Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents. Neoplasia, 2000, 2: 388-17. CrossRef
  
• 作者单位：Ye Huang (1)
  Dengfeng Chen (1)
  Lu Yuan (1)
  Yian Liu (1)
  Hua Liu (1)
  Liu Zhang (1)
  Jun Kong (1)
  Hong Wang (1)
  
  1. Department of General Surgery, Jingzhou Hospital of Tongji Medical College, Huazhong University of Science and Technology, Jingzhou, 434020, China
  

文摘

Objective To detect the reliability of near-infrared parameters of blood oxygen of mammary gland phyma from the microvessel density of tumor. Methods 181 cases of mammary gland phyma who had accepted the examination of the near-infrared TBO-I dual-wave length mammary gland phyma detector were classified by near-infrared parameters of blood oxygen, and were performed the pathologic examination to ascertain whether the tumor was benign or malignant. Among these cases, intratumoral microvessel density of 20 cases of malignant phyma and 20 cases of benign phyma were confirmed by S-P immunohistochemical method, then the relationship between near-infrared parameters and microvessel density were analyzed by medical statistics. Results (1) The microvessel density and blood concentration of 28 cases of the “high blood-tumor were 24.56 ± 8.110 and 1.891 ± 0.850 respectively. The microvessel density and blood concentration of 12 cases of the “low blood-tumor were 17.98 ± 8.729 and 0.698 ± 0.283 respectively. There was significant difference between the “high blood-and “low blood-tumors (P < 0.05). (2) The intratumoral microvessel density and blood concentration were linearly correlated respectively, and the linear correlation coefficient r = 0.4208 (P < 0.05) in 40 cases of mammary gland phyma. Conclusion The intratumoral microvessel density and blood concentration of benign or malignant mammary gland phyma were linearly correlated. Blood concentration (one of near-infrared parameters) is reliable to be used as diagnosis criterion of malignant mammary gland phyma.