miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1

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• 作者：Ye Zhang ; Xiujuan Qu ; Ce Li ; Yibo Fan ; Xiaofang Che ; Ximing Wang ; Ying Cai…
• 关键词：Gastric carcinoma ; miR ; 103/107 ; Multidrug resistance ; Caveolin ; 1
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：36
• 期：4
• 页码：2277-2285
• 全文大小：1,200 KB
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• 作者单位：Ye Zhang (1)
  Xiujuan Qu (1)
  Ce Li (1)
  Yibo Fan (1)
  Xiaofang Che (1)
  Ximing Wang (2)
  Ying Cai (1)
  Xuejun Hu (2)
  Yunpeng Liu (1)
  
  1. Department of Medical Oncology, The First Hospital of China Medical University, NO. 155, North Nanjing Street, Heping District, Shenyang, 110001, China
  2. Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, 110001, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In the present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR and its parent cell line SGC7901 using a miRNA microarray. MiR-103/107 was downregulated compared with parental SGC7901 cells. Overexpression of miR-103/107 sensitized SGC7901/ADR cells to doxorubicin (DOX), as demonstrated by in vitro and in vivo drug sensitivity assay. We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107.