Comparative analysis of curative effect of CT-guided stem cell transplantation and open surgical transplantation for sequelae of spinal cord injury

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• 作者：Guanghui Dai (5)
  Xuebin Liu (5)
  Zan Zhang (5)
  Xiaodong Wang (5)
  Min Li (5)
  Hongbin Cheng (5)
  Rongrong Hua (5)
  Jing Shi (5)
  Renzhi Wang (7)
  Chuan Qin (6)
  Jianhua Gao (7)
  Yihua An (5)
  
• 关键词：Mesenchymal stem cells ; Spinal cord injury ; CT ; guided puncture ; Cell transplantation
• 刊名：Journal of Translational Medicine
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：495 KB
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• 作者单位：Guanghui Dai (5)
  Xuebin Liu (5)
  Zan Zhang (5)
  Xiaodong Wang (5)
  Min Li (5)
  Hongbin Cheng (5)
  Rongrong Hua (5)
  Jing Shi (5)
  Renzhi Wang (7)
  Chuan Qin (6)
  Jianhua Gao (7)
  Yihua An (5)
  
  5. Department of Cell Transplantation, General Hospital of Chinese people鈥檚 Armed Police Forces, Yongding Road, No. 69, Hai Dian District, Beijing, 100039, China
  7. Department of CT Room Radiology, General Hospital of Chinese people鈥檚 Armed Police Forces, Yongding Road, No. 69, Hai Dian District, Beijing, 100039, China
  6. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Yongding Road, No. 69, Hai Dian District, Beijing, 100730, PR China
  
• ISSN：1479-5876

文摘

Background This study compared the clinical efficacies, advantages and disadvantages of two transplantation approaches for treating spinal cord injury: open surgical exploration combined with local stem cell transplantation (referred to as open surgical transplantation) and local stem cell transplantation by CT-guided puncture (referred to as CT-guided transplantation). Methods The patients were divided into the following three groups to perform a retrospective controlled study: Group A included nine patients who underwent open surgical transplantation, Group B included nine patients who underwent CT-guided transplantation, and Group C included nine patients who did not receive stem cell transplantation. The Abbreviated Injury Scale (AIS), the American Spinal Injury Association (ASIA) score and the motor evoked potentials (MEP) examination were utilized to compare the differences in the clinical efficacies. The advantages and disadvantages of the two transplantation approaches were also compared, including the surgical risks, the possibility of repeating the operation, the interval between surgery and rehabilitation exercises and the scope of conditions suitable for the operation. Results Whether evaluated by the AIS grading scale, the ASIA score or the MEP results, there were significant differences in the clinical efficacy among the three patient groups. Group B exhibited the best clinical outcome, followed by Group A, and Group C fared the worst. The CT-guided transplantation had the advantages of lower surgical risk, the potential to repeat the operations within a short time-frame and a short interval between surgery and rehabilitation exercise compared with the open surgical transplantation. The conditions that are suitable for CT-guided transplantation versus the conditions suitable for open surgical transplantation are not identical. The application scopes for the two approaches had their respective strengths. Conclusions CT-guided stem cell transplantation was confirmed as a safe and effective approach to treat sequelae of spinal cord injury with the advantages of simpler operation, minimal invasion, less adverse reaction and quicker recovery. Trial registration Clinical trials registration number: ChiCTR-TNRC-12002477.