Predictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology

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• 作者：Ozge Gumusay (1)
  Ugur Coskun (1)
  Tülay Akman (2)
  Ahmet Siyar Ekinci (3)
  Muharrem Kocar (4)
  ?zlem Balvan Erceleb (5)
  Ozan Yaz?c? (6)
  Mehmet Ali Kaplan (7)
  Veli Berk (8)
  Bulent Cetin (1)
  Burcu Yapar Taskoylu (9)
  Ayhan Yildiz (10)
  Gamze Goksel (11)
  Ahmet Alacacioglu (12)
  Umut Demirci (3)
  Efnan Algin (1)
  Mukremin Uysal (13)
  Ilhan Oztop (14)
  Berna Oksuzoglu (3)
  Faysal Dane (4)
  Mahmut Gumus (5)
  Suleyman Buyukberber (1)
  
• 关键词：Melanoma ; Brain metastases ; Predictive factors
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：140
• 期：1
• 页码：151-157
• 全文大小：356 KB
• 作者单位：Ozge Gumusay (1)
  Ugur Coskun (1)
  Tülay Akman (2)
  Ahmet Siyar Ekinci (3)
  Muharrem Kocar (4)
  ?zlem Balvan Erceleb (5)
  Ozan Yaz?c? (6)
  Mehmet Ali Kaplan (7)
  Veli Berk (8)
  Bulent Cetin (1)
  Burcu Yapar Taskoylu (9)
  Ayhan Yildiz (10)
  Gamze Goksel (11)
  Ahmet Alacacioglu (12)
  Umut Demirci (3)
  Efnan Algin (1)
  Mukremin Uysal (13)
  Ilhan Oztop (14)
  Berna Oksuzoglu (3)
  Faysal Dane (4)
  Mahmut Gumus (5)
  Suleyman Buyukberber (1)
  
  1. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Besevler, Ankara, 06500, Turkey
  2. Division of Medical Oncology, Department of Internal Medicine, Bal?kesir State Hospital, Bal?kesir, Turkey
  3. Division of Medical Oncology, Department of Internal Medicine, Dr. Abdurrahman Yurtaslan Training and Research Hospital, Ankara, Turkey
  4. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey
  5. Division of Medical Oncology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey
  6. Department of Internal Medicine, Division of Medical Oncology, Numune Training and Research Hospital, Ankara, Turkey
  7. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
  8. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  9. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey
  10. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Inonu University, Malatya, Turkey
  11. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
  12. Division of Medical Oncology, Department of Internal Medicine, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
  13. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
  14. Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
  
• ISSN：1432-1335

文摘

Background The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6?months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-0?%. Our aim was to identify factors predicting development of BMs and survival. Patients and methods We performed a retrospective analysis of 470 melanoma patients between 2000 and 2012. The logistic regression analyses were used to identify the clinicopathological features of primary melanoma that are predictive of BMs development and survival after a diagnosis of brain metastases. Results There were 52 patients (11.1?%) who developed melanoma BMs during the study period. The analysis of post-BMs with Kaplan–Meier curves has resulted in a median survival rate of 4.1?months (range 2.9-.1?months). On logistic regression analysis site of the primary tumor on the head and neck (p?=?0.002), primary tumor thickness (Breslow >4?mm) (p?=?0.008), ulceration (p?=?0.007), and pathologically N2 and N3 diseases (p?=?0.001) were found to be significantly associated with the development of BMs. In univariate analysis, tumor thickness and performance status had a significant influence on post-BMs survival. In multivariate analysis, these clinicopathologic factors were not remained as significant predictive factors. Conclusions Our results revealed the importance of primary tumor characteristics associated with the development of BMs. Ulceration, primary tumor thickness, anatomic site, and pathologic ≥N2 disease were found to be significant predictors of BMs development.