Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake?
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- 作者：Shi-Sheng Zhou ; Da Li ; Yiming Zhou
- 关键词：1 ; Methylnicotinamide ; Cancer ; Insulin resistance ; NAD+ ; Nicotinamide ; Nicotinamide N ; methyltransferase ; Nicotinic acid ; Obesity ; Type 2 diabetes
- 刊名：Diabetologia
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：58
- 期：9
- 页码：2191-2192
- 全文大小：241 KB
- 参考文献：1.Kannt A, Pfenninger A, Teichert L et al (2015) Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia 58:799鈥?08PubMed Central PubMed View Article
2.Tian YJ, Luo N, Chen NN et al (2014) Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats. Br J Nutr 111:1594鈥?601PubMed View Article
3.Li D, Sun WP, Zhou YM et al (2010) Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol 16:2378鈥?387PubMed Central PubMed View Article
4.Zhou SS, Li D, Zhou YM, Sun WP, Liu QG (2010) B-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study. BMC Public Health 10:746PubMed Central PubMed View Article
5.Zhou SS, Zhou Y (2014) Excess vitamin intake: an unrecognized risk factor for obesity. World J Diabetes 5:1鈥?3PubMed Central PubMed View Article
6.Sun WP, Li D, Lun YZ et al (2012) Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. Hypertens Res 35:180鈥?85PubMed View Article
7.Zhou SS, Li D, Sun WP et al (2009) Nicotinamide overload may play a role in the development of type 2 diabetes. World J Gastroenterol 15:5674鈥?684PubMed Central PubMed View Article
8.Donmez G, Outeiro TF (2013) SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med 5:344鈥?52PubMed Central PubMed View Article - 作者单位：Shi-Sheng Zhou (1)
Da Li (2)
Yiming Zhou (3)
1. Institute of Basic Medical Sciences, Medical College, Dalian University, No.10 Xuefu Avenue, Dalian Economic and Technological Development Zone, Dalian, 116622, People鈥檚 Republic of China
2. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, People鈥檚 Republic of China
3. Renal Division, Department of Medicine, Brigham and Women鈥檚 Hospital, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Internal Medicine
Metabolic Diseases
Human Physiology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0428
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