Serial interferon-gamma release assays after chemoprophylaxis in a tuberculosis outbreak cohort

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• 作者：S. W. Lee (24)
  S. H. Lee (3)
  J.-J. Yim (1) yimjj@snu.ac.kr
• 关键词：Interferon ; γ ; release assay – ; Tuberculosis – ; Latent tuberculosis infection
• 刊名：Infection
• 出版年：2012
• 出版时间：August 2012
• 年：2012
• 卷：40
• 期：4
• 页码：431-435
• 全文大小：190.0 KB
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• 作者单位：1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-744 Republic of Korea2. Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Republic of Korea3. Molecular Biology Section, Korean Institute of Tuberculosis, Seoul, Republic of Korea4. Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
• ISSN：1439-0973

文摘

Purpose Interferon-gamma release assay (IGRA) results have been suggested as a surrogate marker of treatment response in latent tuberculosis infection (LTBI). However, data have not been consistent, and most previous studies focused on participants taking isoniazid prophylaxis. The aim of this study was to elucidate the changes in the IGRA results in patients who underwent chemoprophylaxis with isoniazid and rifampicin daily for 3 months.