Placental mesenchymal stem cells of fetal and maternal origins demonstrate different therapeutic potentials

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• 作者：Yongzhao Zhu (1) (2)
  Yinxue Yang (1)
  Yaolin Zhang (1) (4)
  Guiliang Hao (1) (4)
  Ting Liu (1)
  Libin Wang (1) (3)
  Tingting Yang (1)
  Qiong Wang (1)
  Guangyi Zhang (1)
  Jun Wei (1) (3)
  Yukui Li (1) (3)
  
  1. Institute of Stem Cell Research ; General Hospital of Ningxia Medical University ; Yinchuan ; 750004 ; China
  2. Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China ; College of Life science ; Ningxia University ; Yinchuan ; 750021 ; China
  4. School of Laboratory Medicine ; Ningxia Medical University ; Yinchuan ; 750004 ; China
  3. Key Laboratory of Fertility Preservation and Maintenance ; Ministry of Education ; Ningxia Medical University ; Yinchuan ; 750004 ; China
  
• 刊名：Stem Cell Research & Therapy
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：5
• 期：2
• 全文大小：1,741 KB
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• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Introduction Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics and functions, inconsistent or controversial results of pre-clinical and clinical applications of such cells are frequently reported. This may be partially due to the fact that MSCs isolated from different origins may differentially express some functions not typical for MSCs, and hence have different therapeutic potentials. The aim of this study is to investigate the differences in human placental MSCs (P-MSCs) of fetal and maternal origins in the aspects of clinical importance. Methods P-MSCs of fetal and maternal origins isolated from normal term placentas were characterized for their typical phenotype as well as their expression of receptors and growth factors of clinic interests. P-MSCs that preferentially express hepatocyte growth factor (HGF) and CD200 were evaluated for their therapeutic potentials in models of angiogenesis and allogeneic skin transplantation, in comparison with their HGF and CD200 negative partners. Results Although all P-MSCs express typical MSC phenotype, fetal but not maternal P-MSCs express high levels of CD200 and HGF. Compared with HGF and CD200 negative P-MSCs, HGF and CD200 positive cells demonstrated significantly high potentials in promoting angiogenesis in vitro and increasing immunosuppressive function in vivo. These therapeutic potentials were at least in part due to their differences in HGF and CD200 expression, respectively. Conclusions We conclude that MSC origins may have significant impact on the therapeutic potentials of such cells, and should be taken into consideration in clinical applications.