Biological correlates of psychological states among young children: a cross-sectional examination of roles of aspartate transaminase/alanine aminotransferase, insulin, and cytokines

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• 作者：Kuo-Hsuan Chung (1) (2)
  Chien-Ming Hu (3) (4)
  Ying-Ru Chen (5)
  Hung-Yi Chiou (6)
  Yi-Hua Chen (6)
  
• 关键词：Anxiety ; Depression ; Aspartate transaminase (AST) ; Alanine aminotransferase (ALT) ; Interleukin ; 10 ; Interleukin ; 1β
• 刊名：Chinese Science Bulletin
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：59
• 期：35
• 页码：5102-5112
• 全文大小：382 KB
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• 作者单位：Kuo-Hsuan Chung (1) (2)
  Chien-Ming Hu (3) (4)
  Ying-Ru Chen (5)
  Hung-Yi Chiou (6)
  Yi-Hua Chen (6)
  
  1. Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan, China
  2. Department of Psychiatry, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan, China
  3. Emergency Department, Taipei Medical University Hospital, Taipei, 110, Taiwan, China
  4. Department of General Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan, China
  5. Department of Psychiatry, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 235, Taiwan, China
  6. School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, 110, Taiwan, China
  
• ISSN：1861-9541

文摘

Compared to data on adolescents and adults, limited research has been conducted on biological correlates among young children with possible psychological difficulties, especially in Asian countries. By focusing on various peripheral biochemical indicators, we investigated potential biological correlates of psychological states in a community sample of Taiwanese school children aged 6-0?years. In total, 307 students (159 obese children and 148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009. These children underwent a comprehensive health examination, including a physical examination, blood sample analysis, and questionnaire administration in a hospital. Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains. We found that interleukin (IL)-1β [β?=?1.29, 95?% confidence interval (CI) 0.50-.09], IL-10 (β?=?1.61, 95?% CI β?=?0.08, 95?% CI 0.01-.15), homocysteine (β?=?0.63, 95?% CI 0.09-.18), and aspartate transaminase (AST) (β?=?0.15, 95?% CI