Blocked-micropores, surface functionalized, bio-compatible and silica-coated iron oxide nanocomposites as advanced MRI contrast agent

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• 作者：Masih Darbandi (1) (6)
  Sophie Laurent (2)
  Martin Busch (3)
  Zi-An Li (1)
  Ying Yuan (4)
  Michael Krüger (4)
  Michael Farle (1)
  Markus Winterer (3)
  Luce Vander Elst (2)
  Robert N. Muller (2) (5)
  Heiko Wende (1)
  
• 关键词：Surface functionalization ; MRI contrast agent ; Silica shell ; Nanoparticles ; Blocked ; micropores ; Iron oxide
• 刊名：Journal of Nanoparticle Research
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：15
• 期：5
• 全文大小：455 KB
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• 作者单位：Masih Darbandi (1) (6)
  Sophie Laurent (2)
  Martin Busch (3)
  Zi-An Li (1)
  Ying Yuan (4)
  Michael Krüger (4)
  Michael Farle (1)
  Markus Winterer (3)
  Luce Vander Elst (2)
  Robert N. Muller (2) (5)
  Heiko Wende (1)
  
  1. Faculty of Physics and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, 47048, Duisburg, Germany
  6. Department of Physics and Vanderbilt Institute of Nanoscale Science and Engineering (VINSE), Vanderbilt University, Nashville, TN, 37234-0106, USA
  2. Department of General, Organic and Biomedical Chemistry NMR and Molecular Imaging Laboratory, University of Mons, 7000, Mons, Belgium
  3. Nanoparticle Process Technology, Faculty of Engineering and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, 47048, Duisburg, Germany
  4. Department of Microsystems Engineering and Freiburg Materials Research Centre, University of Freiburg, Freiburg, Germany
  5. Center for Microscopy and Molecular Imaging, 6041, Gosselies, Belgium
  
• ISSN：1572-896X

文摘

Biocompatible magnetic nanoparticles have been found promising in several biomedical applications for tagging, imaging, sensing and separation in recent years. In this article, a systematic study of the design and development of surface-modification schemes for silica-coated iron oxide nanoparticles (IONP) via a one-pot, in situ method at room temperature is presented. Silica-coated IONP were prepared in a water-in-oil microemulsion, and subsequently the surface was modified via addition of organosilane reagents to the microemulsion system. The structure and the morphology of the as synthesized nanoparticles have been investigated by means of transmission electron microscopy (TEM) and measurement of N2 adsorption–desorption. Electron diffraction and high-resolution transmission electron microscopic (TEM) images of the nanoparticles showed the highly crystalline nature of the IONP structures. Nitrogen adsorption indicates microporous and blocked-microporous structures for the silica-coated and amine functionalized silica-coated IONP, respectively which could prove less cytotoxicity of the functionalized final product. Besides, the colloidal stability of the final product and the presence of the modified functional groups on top of surface layer have been proven by zeta-potential measurements. Owing to the benefit from the inner IONP core and the hydrophilic silica shell, the as-synthesized nanocomposites were exploited as an MRI contrast enhancement agent. Relaxometric results prove that the surface functionalized IONP have also signal enhancement properties. These surface functionalized nanocomposites are not only potential candidates for highly efficient contrast agents for MRI, but could also be used as ultrasensitive biological-magnetic labels, because they are in nanoscale size, having magnetic properties, blocked-microporous and are well dispersible in biological environment.