Hematopoietic stem cells: multiparameter regulation

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• 作者：Kedong Song ; Liying Li ; Yiwei Wang ; Tianqing Liu
• 关键词：Hematopoietic stem cells (HSCs) ; Ex vivo expansion ; Multiparameter regulation
• 刊名：Human Cell
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：29
• 期：2
• 页码：53-57
• 全文大小：361 KB
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• 作者单位：Kedong Song (1)
  Liying Li (1)
  Yiwei Wang (2)
  Tianqing Liu (1)
  
  1. State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China
  2. Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW, 2139, Australia
  
• 刊物主题：Cell Biology; Embryology; Oncology; Stem Cells; Reproductive Medicine; Cell Culture;
• 出版者：Springer Japan
• ISSN：1749-0774

文摘

Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.