Image-guided nanomedicine for cancer
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- 作者：Jong Hoon Choi ; Yong Jae Lee ; Dongin Kim
- 关键词：Theranostic ; Organic nanoparticles ; Inorganic nanoparticles ; Cancer
- 刊名：Journal of Pharmaceutical Investigation
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：47
- 期：1
- 页码：51-64
- 全文大小：1071KB
- 刊物主题：Biomedicine, general;
- 出版者：Springer Netherlands
- ISSN：2093-6214
- 卷排序：47
文摘
Since current treatment options applicable to cancers are still confined to chemotherapeutics followed by surgical debulking, cancer disease is a second leading cause of death because of chemotherapeutics of non-specific biodistribution. Image-guided drug delivery system (IGDDS) is a real-time noninvasive imaging assessment of therapeutic response that has the strong potential to control or suppress cancer because imaging property offer the quantification of nanomedicine at the intended disease site, thus the potential assurance of adequate treatment and elimination of undesirable delay leading to poor clinical outcomes. Also, combining pH-sensitive advantages of nanoparticle with theranostic property will have high chance to overcome cancer. There have been intensive researches to develop innovative IGDDS by using nanoparticles including organic or inorganic theranostic (therapy + diagnostic) systems including liposomes, polymeric micelles, dendrimers, carbon nanotubes, gold nanoparticles, iron oxide nanoparticles, quantum dots, and silica nanoparticles. In this review, we will introduce various examples of each system and will discuss their theranostic applications.