Size-dependent clearance of gold nanoparticles from lungs of Sprague–Dawley rats after short-term inhalation exposure

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• 作者：Sung Gu Han ; Jong Seong Lee ; Kangho Ahn ; Yong Soon Kim…
• 关键词：Gold nanoparticles ; Biopersistence ; Clearance ; Size difference ; Tissue distribution
• 刊名：Archives of Toxicology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：89
• 期：7
• 页码：1083-1094
• 全文大小：1,308 KB
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• 作者单位：Sung Gu Han (1)
  Jong Seong Lee (2)
  Kangho Ahn (3)
  Yong Soon Kim (4)
  Jin Kwon Kim (5)
  Ji Huyn Lee (5)
  Jae Hoon Shin (2)
  Ki Soo Jeon (3)
  Wan Seob Cho (6)
  Nam Woong Song (7)
  Mary Gulumian (8)
  Beom Soo Shin (9)
  Il Je Yu (5)
  
  1. Toxicology Laboratory, College of Animal Bioscience and Technology, Konkuk University, Seoul, Korea
  2. Occupational Lung Diseases Institute, Korea Workers-Compensation Welfare Service, Ansan, Korea
  3. Department of Mechanical Engineering, Hanyang University, Ansan, Korea
  4. Korea Ginseng Corporation, Daejeon, Korea
  5. Institute of Nanoproduct Safety Research, Hoseo University, 165 Sechul-ri, Baebang-myun, Asan, 336-795, Korea
  6. Dong-A University, Busan, Korea
  7. Korea Research Institute of Standards and Science, Daejeon, Korea
  8. Toxicology Department, National Institute for Occupational Health, Johannesburg, South Africa
  9. College of Pharmacy, Catholic University of Daegu, Daegu, South Korea
  
• 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0738

文摘

Gold nanoparticles are known to be distributed to many tissues following their oral, inhalation, or intravenous exposure. Information on the biodistribution and clearance of gold nanoparticles from these tissues is, therefore, important to understand their behavior in vivo. To study the effect of size on the biodistribution of gold nanoparticles, Sprague–Dawley rats were exposed by inhalation to small gold nanoparticles (13?nm in diameter on average) at an exposure concentration of 12.8?±?2.42?μg/m3, and to large gold nanoparticles (105?nm in diameter on average) at an exposure concentration of 13.7?±?1.32?μg/m3. The experimental animals were exposed to the gold nanoparticles and the control animals to fresh air for 5?days (6?h/day), followed by a recovery period of 1, 3, and 28?days in fresh air. None of the exposed animals exhibited any toxic response to the gold nanoparticles. Despite the difference in size, both small and large gold nanoparticles deposited mainly in rat lungs. Their biodistribution from the lungs to secondary target organs was significantly higher with the small compared to the large gold nanoparticles. While the large gold nanoparticles were only found in the blood, the small gold nanoparticles were detected in the liver, spleen, brain, testes, and blood. In addition, the elimination half-life of the small gold nanoparticles from the lungs was significantly shorter than that of the large gold nanoparticles. The present data may, therefore, suggest that the smaller gold nanoparticles are able to translocate from the lungs, the primary exposure organ to extrapulmonary organs at a faster rate than the larger gold nanoparticles and thus confirming previous observations reported in the literature.