Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

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• 作者：Xiangxiang Du ; Guohua Jiang ; Lei Li ; Yongkun Liu ; Hua Chen…
• 关键词：Photopolymerization ; Glucose sensitive ; Insulin ; Drug release
• 刊名：Colloid & Polymer Science
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：293
• 期：7
• 页码：2129-2135
• 全文大小：1,106 KB
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• 作者单位：Xiangxiang Du (1)
  Guohua Jiang (1) (2) (3)
  Lei Li (2) (3)
  Yongkun Liu (2) (3)
  Hua Chen (2) (3)
  Qin Huang (2) (3)
  
  1. Department of Materials Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, People鈥檚 Republic of China
  2. National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou, 310018, People鈥檚 Republic of China
  3. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou, 310018, People鈥檚 Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

The glucose-responsive amphiphilic poly(PEGMA-co-AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA-co-AAPBA) micelles were characterized by 1H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems.