Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

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• 作者：Yongning Xin ; Wei Li ; Linlin Lu ; Li Zhou…
• 刊名：Journal of Ocean University of China
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：15
• 期：4
• 页码：719-725
• 全文大小：593 KB
• 刊物主题：Oceanography; Meteorology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1993-5021
• 卷排序：15

文摘

Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.KeywordsStichopus japonicus acid mucopolysaccharidehepatitis B virustransgenic miceantiviral