Synthesis and thermo-sensitive property of star poly(N-isopropylacrylamide) with α -D-glucose-based group

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• 作者：Yuan Cui ; Yongsong Xu ; Jingpeng Zhang ; Qian Duan
• 关键词：α ; D ; glucose ; Atom transfer radical polymerization (ATRP) ; N ; isopropylacrylamide ; Lower critical solution temperature (LCST)
• 刊名：Journal of Polymer Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：23
• 期：2
• 全文大小：953 KB
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• 作者单位：Yuan Cui (1)
  Yongsong Xu (1)
  Jingpeng Zhang (1)
  Qian Duan (1)
  
  1. School of Materials Science and Technology, Changchun University of Science and Technology, Changchun, 130022, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Industrial Chemistry and Chemical Engineering
  Characterization and Evaluation Materials
  
• 出版者：Springer Netherlands
• ISSN：1572-8935

文摘

Polymers containing functional biological activity groups have potential biological application. A new type of initiator (Glu-Br) synthesized by α-D-glucose and excessive 2-bromo-isobutyrlbromide was used to initiate NIPAM polymerization by atom transfer radical polymerization in DMF/Water mixture solvent, HMTETA as ligand and CuCl as catalyst. A star polymer was obtained with the reaction molar ratio of [NIPAM]₀:[Glu-Br]₀:[CuCl]₀: [HMTETA]₀ = 100:1:5:1. The polymerization reached a low polydispersity (PDI = 1.15–1.47) with the linearity plot of the M_n,GPC against conversion, and the reaction time revealed the well-controlled polymerization by ATRP. The LCST(lower critical solution temperature) of the star polymer was increased with the molecular weight increasing. Used fluorescein dye molecules as model drug to loaded in the star polymer to measure its envelope ability. The results indicated that the polymer has a promising application in the field of drug controlled release system.