Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death

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• 作者：Yongtao Zhang ; Xiaolei Bi ; Fan Jiang
• 关键词：NADPH oxidase ; Redox signaling ; Cell death ; Stress response ; Autophagy ; Apoptosis
• 刊名：Archives of Toxicology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：89
• 期：7
• 页码：991-1006
• 全文大小：805 KB
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• 作者单位：Yongtao Zhang (1)
  Xiaolei Bi (1)
  Fan Jiang (1)
  
  1. Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, 107 Wen Hua Xi Road, Jinan, 250012, Shandong Province, China
  
• 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0738

文摘

Numerous studies have shown that a variety of cytotoxic agents can activate the NADPH oxidase system and induce redox-dependent regulation of cellular functions. Cytotoxin-induced NADPH oxidase activation may either exert cytoprotective actions (e.g., survival, proliferation, and stress tolerance) or cause cell death. Here we summarize the experimental evidence showing the context-dependent dichotomous effects of NADPH oxidase on cell fate under cytotoxic stress conditions and the potential redox signaling mechanisms underlying this phenomenon. Clearly, it is difficult to create a unified paradigm on the toxicological implications of NADPH oxidase activation in response to cytotoxic stimuli. We suggest that interventional strategies targeting the NADPH oxidase system to prevent the adverse impacts of cytotoxins need to be contemplated in a stimuli- and cell type-specific manner.