Evaluation of the Etoricoxib-Mediated Pain-Relieving Effect in Patients Undergoing Lumbar Fusion Procedures for Degenerative Lumbar Scoliosis: A Prospective Randomized, Double-Blind Controlled Study

详细信息    查看全文

• 作者：Yongxiang Shi ; Ping Wang ; Xinlei Hu ; Zhaoming Ye
• 关键词：Etoricoxib ; Fusion procedures ; Degenerative lumbar scoliosis ; Non ; steroidal anti ; inflammatory agents
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：71
• 期：3
• 页码：1313-1318
• 全文大小：464 KB
• 参考文献：1.Cho, K. J., et al. (2014). Surgical treatment of adult degenerative scoliosis. Asian Spine Journal, 8(3), 371鈥?81.View Article PubMed Central PubMed
  2.Chin, K. R., Furey, C., & Bohlman, H. H. (2009). Risk of progression in de novo low-magnitude degenerative lumbar curves: natural history and literature review. American Journal of Orthopedics (Belle Mead NJ), 38(8), 404鈥?09.
  3.Ploumis, A., Transfledt, E. E., & Denis, F. (2007). Degenerative lumbar scoliosis associated with spinal stenosis. Spine Journal, 7(4), 428鈥?36.View Article PubMed
  4.Aebi, M. (2005). The adult scoliosis. European Spine Journal, 14(10), 925鈥?48.View Article PubMed
  5.Oskouian, R. J, Jr, & Shaffrey, C. I. (2006). Degenerative lumbar scoliosis. Neurosurgery Clinics of North America, 17(3), 299鈥?15.View Article PubMed
  6.Gross, P. (2013). Low back pain in the elderly. Therapeutische Umschau., 70(9), 523鈥?28.View Article PubMed
  7.Mobbs, R. J., et al. (2013). Indications for anterior lumbar interbody fusion. Orthopaedic Surgery, 5(3), 153鈥?63.View Article PubMed
  8.Binder, D. K., Schmidt, M. H., & Weinstein, P. R. (2002). Lumbar spinal stenosis. Seminars in Neurology, 22(2), 157鈥?66.View Article PubMed
  9.Madigan, L., et al. (2009). Management of symptomatic lumbar degenerative disk disease. Journal of American Academy of Orthopaedic Surgeons, 17(2), 102鈥?11.
  10.Hart, R. A., & Prendergast, M. A. (2007). Spine surgery for lumbar degenerative disease in elderly and osteoporotic patients. Instructional Course Lectures, 56, 257鈥?72.PubMed
  11.Bono, C.M. and Lee, C.K. The influence of subdiagnosis on radiographic and clinical outcomes after lumbar fusion for degenerative disc disorders: an analysis of the literature from two decades. Spine (Phila Pa 1976), 2005. 30(2): p. 227-34.
  12.Resnick, D. K., et al. (2005). Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 1: introduction and methodology. Journal of Neurosurgery Spine, 2(6), 637鈥?38.View Article PubMed
  13.Llanora, G. V., et al. (2013). Etoricoxib: A safe alternative for NSAID intolerance in Asian patients. Asian Pacific Journal of Allergy and Immunology, 31(4), 330鈥?33.View Article PubMed
  14.Martina, S. D., Vesta, K. S., & Ripley, T. L. (2005). Etoricoxib: A highly selective COX-2 inhibitor. Annals of Pharmacotherapy, 39(5), 854鈥?62.View Article PubMed
  15.Gatti, D., & Adami, S. (2010). Coxibs: A significant therapeutic opportunity. Acta Bio-medica, 81(3), 217鈥?24.PubMed
  16.Capel, M., et al. (2014). Efficiency of naproxen/esomeprazole in association for osteoarthrosis treatment in Spain. Reumatologia Clinica, 10(4), 210鈥?17.View Article PubMed
  17.van der Heijde, D., et al. (2005). Evaluation of the efficacy of etoricoxib in ankylosing spondylitis: Results of a fifty-two-week, randomized, controlled study. Arthritis and Rheumatism, 52(4), 1205鈥?215.View Article PubMed
  18.Colebatch, A. N., Marks, J. L., & Edwards, C. J. (2011). Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis). Cochrane Database of Systematic Reviews, 11, CD008872.PubMed
  19.Croom, K. F., & Siddiqui, M. A. (2009). Etoricoxib: A review of its use in the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis. Drugs, 69(11), 1513鈥?532.View Article PubMed
  20.Alekseeva, L. I. (2010). Comparative evaluation of the safety and efficacy of etoricoxib and diclofenac on the upper gastrointestinal tract in patients with osteoarthrosis and rheumatoid arthritis (the multinational etoricoxib and diclofenac arthritis long-term (MEDAL) study program). Terapevticheskii Arkhiv, 82(8), 57鈥?2.PubMed
  21.Sheldon, E. A., et al. (2008). Correlation of measures of pain, function, and overall response: results pooled from two identical studies of etoricoxib in chronic low back pain. Spine (Phila Pa 1976), 33(5), 533鈥?38.View Article
  22.Srivastava, S., et al. (2012). Effects of preoperative single dose Etoricoxib on postoperative pain and sleep after lumbar diskectomy: prospective randomized double blind controlled study. Middle East Journal of Anesthesiology, 21(5), 725鈥?30.PubMed
  23.Clarke, R., Derry, S., & Moore, R. A. (2012). Single dose oral etoricoxib for acute postoperative pain in adults. Cochrane Database of Systematic Reviews, 4, CD004309.PubMed
  24.Honeyman, C. (2014). Raising awareness of scoliosis among children鈥檚 nurses. Nursing Children and Young People, 26(5), 30鈥?7.View Article PubMed
  25.Blondell, R. D., Azadfard, M., & Wisniewski, A. M. (2013). Pharmacologic therapy for acute pain. American Family Physician, 87(11), 766鈥?72.PubMed
  
• 作者单位：Yongxiang Shi (1)
  Ping Wang (2)
  Xinlei Hu (1)
  Zhaoming Ye (1)
  
  1. Department of Orthopaedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China
  2. International Health Care Center, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

This randomized, double-blind study was carried out to evaluate the effectiveness of etoricoxib in controlling the pain during lumbar fusion surgery of the degenerative lumbar scoliosis patients. We found that perioperative use of etoricoxib produced a significant reduction in the degree of pain compared to the patients treated with placebo. Etoricoxib eased the pain and helped to manage the discomfort of lumbar fusion surgery. In addition, etoricoxib was well tolerated as it caused no serious adverse reaction, suggesting a safe profile. Etoricoxib also appeared to ensure and promote the positive effect of surgery, however, insignificantly. Thus, the results suggest that etoricoxib was effective in safely managing the pain during the lumbar fusion surgery and recovery thereafter.