Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore
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- 作者：Hye Jin Yoon (1)
In Hee Bae (1)
Hyoung Jun Kim (1)
Jung Mi Jang (1)
Yong Su Hur (1)
Hae Kwon Kim (3)
San Hyun Yoon (2)
Won Don Lee (1)
Jin Ho Lim (1) - 关键词：ICSI ; Artificial oocyte activation ; Fertilization failure ; Origin of spermatozoa
- 刊名：Journal of Assisted Reproduction and Genetics
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：30
- 期：12
- 页码：1569-1575
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- 作者单位：Hye Jin Yoon (1)
In Hee Bae (1)
Hyoung Jun Kim (1)
Jung Mi Jang (1)
Yong Su Hur (1)
Hae Kwon Kim (3)
San Hyun Yoon (2)
Won Don Lee (1)
Jin Ho Lim (1)
1. Maria Fertility Hospital, 103-11, Sinseol-Dong, Dongdaemun-Gu, Seoul, 130-812, Republic of Korea
3. Department of Biotechnology, College of Natural Science, Seoul Women? University, 621, Hwarang-Lo, Nowon-Gu, Seoul, 139-794, Republic of Korea
2. Maria Research Center, 103-11, Sinseol-Dong, Dongdaemun-Gu, Seoul, 130-812, Republic of Korea - ISSN：1573-7330
文摘
Purpose Fertilization failures have occurred repeatedly in reproductive centers after intracytoplasmic sperm injection (ICSI) and artificial oocyte activation (AOA) has been used to prevent it. This study was performed to investigate whether spermatozoan origin influences clinical outcomes of AOA with a calcium ionophore. Methods A total of 185 ICSI cycles with a history of no or low fertilization was included in this retrospective study. The outcomes of AOA after ICSI were compared with ejaculated-normal, ejaculated-oligo-astheno-terato or extracted-testicular spermatozoa. Results There were significant differences between the previous standard ICSI cycles and AOA cycles in the rate of fertilization and clinical outcomes among cases with different sperm origins. Thirty-eight healthy babies (20 singles and 18 twins, 29?cycles) were successfully delivered, and no congenital birth defects were observed. Conclusions Most patients with a no or low fertilization history obtained an increased fertilization rate and a positive clinical outcome with AOA regardless of the origin of spermatozoa.