Low concentrations of doxycycline attenuates FasL-induced apoptosis in HeLa cells

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• 作者：Jung Mi Yoon ; Sushruta Koppula ; Se Jong Huh ; Sun Jin Hur…
• 关键词：Apoptosis ; Caspase ; Cisplatin ; FasL ; Hydrogen peroxide ; Tetracycline
• 刊名：Biological Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：48
• 期：1
• 全文大小：1383KB
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• 作者单位：Jung Mi Yoon (1)
  Sushruta Koppula (1)
  Se Jong Huh (1)
  Sun Jin Hur (2)
  Chan Gil Kim (1)
  
  1. Department of Biotechnology, Konkuk University, Chungju, 380-701, Republic of Korea
  2. Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi, 456-756, South Korea
  
• 刊物类别：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Scie
• 刊物主题：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Sciences;
• 出版者：BioMed Central
• ISSN：0717-6287

文摘

Background Doxycycline (DC) has been shown to possess non-antibiotic properties including Fas/Fas Ligand (FasL)-mediated apoptosis against several tumor types in the concentration range of 10鈥?0 碌g/mL. However, the effect of DC in apoptotic signaling at much low concentrations was not studied.