Creatinine-based equations to estimate glomerular filtration rate in Japanese children aged between 2 and 11years old with chronic kidney disease

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• 作者：Takuhito Nagai (1)
  Osamu Uemura (1) (2)
  Kenji Ishikura (1)
  Shuichi Ito (1)
  Hiroshi Hataya (1)
  Yoshimitsu Gotoh (1)
  Naoya Fujita (1)
  Yuko Akioka (1)
  Tetsuji Kaneko (1)
  Masataka Honda (1)
  
• 关键词：Estimate glomerular filtration rate ; Japanese children ; Creatinine ; based equation ; Chronic kidney disease
• 刊名：Clinical and Experimental Nephrology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：17
• 期：6
• 页码：877-881
• 全文大小：
• 作者单位：Takuhito Nagai (1)
  Osamu Uemura (1) (2)
  Kenji Ishikura (1)
  Shuichi Ito (1)
  Hiroshi Hataya (1)
  Yoshimitsu Gotoh (1)
  Naoya Fujita (1)
  Yuko Akioka (1)
  Tetsuji Kaneko (1)
  Masataka Honda (1)
  
  1. The Japanese Society for Pediatric Nephrology, the Committee of Measures for Pediatric CKD, Tokyo, Japan
  2. Department of Pediatric Nephrology, Aichi Children Health and Medical Center, 1-2 Osakada Morioka-cho, Obu, Aichi, 474-8710, Japan
  
• ISSN：1437-7799

文摘

Background Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measuring serum Cr by enzymatic method. The updated Schwartz formulae were reported by enzymatic Cr instead of by the Jaffe method in American children aged 16years old. We believe it would be better to determine serum Cr-based eGFR by the enzymatic method in Japanese children for evaluation of renal function. Methods Serum Cr-based eGFR was determined by measuring inulin clearance and serum Cr level in 76 pediatric chronic kidney disease (CKD) patients (49 males and 27 females) aged 21years with no underlying disease that would affect renal function. Results We showed the inulin clearance by expression of the body length/serum Cr ratio in pediatric CKD patients, which resulted in the equation: $ {\text{inulin}}\;{\text{GFR}} = 0. 3 4 2 \times {\text{body length}}\;({\text{cm}})/{\text{serum}}\;{\text{Cr}}\;({\text{mg}}/{\text{dL}}) \pm 2. 7 5 $ . Additionally, we suggest the following serum Cr-based eGFR formula passing through the origin: $ {\text{eGFR}}\; ( {\text{mL}}/{ \hbox{min} }/ 1. 7 3 \,{\text{m}}^{ 2} )= 0. 3 5 \times {\text{body}}\;{\text{length}}\; ( {\text{cm)/serum}}\;{\text{Cr}}\; ( {\text{mg}}/{\text{dL)}} $ , because it is simple and easy to remember, thus making it clinically useful. Conclusion The new eGFR formula derived from body length and serum Cr level is applicable for clinical screening of renal function in Asian as well as Japanese children aged between 2 and 11years old.