Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease
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- 作者：Osamu Uemura (1)
Takuhito Nagai (1)
Kenji Ishikura (2)
Shuichi Ito (3)
Hiroshi Hataya (2)
Yoshimitsu Gotoh (4)
Naoya Fujita (5)
Yuko Akioka (6)
Tetsuji Kaneko (7)
Masataka Honda (2) - 关键词：Estimate glomerular filtration rate ; Japanese children and adolescents ; Creatinine ; based equation ; Chronic kidney disease
- 刊名：Clinical and Experimental Nephrology
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：18
- 期：4
- 页码：626-633
- 全文大小：402 KB
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Takuhito Nagai (1)
Kenji Ishikura (2)
Shuichi Ito (3)
Hiroshi Hataya (2)
Yoshimitsu Gotoh (4)
Naoya Fujita (5)
Yuko Akioka (6)
Tetsuji Kaneko (7)
Masataka Honda (2)
1. Department of Pediatric Nephrology, Aichi Children’s Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan
2. Department of Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
3. Department of Nephrology, National Center for Child Health and Development, Tokyo, Japan
4. Department of Pediatric Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
5. Department of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan
6. Department of Pediatric Nephrology, Tokyo Women’s Medical University, Tokyo, Japan
7. Department of Clinical Research, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan - ISSN：1437-7799
文摘
Background Renal inulin clearance is the gold standard for evaluation of kidney function, but cannot be measured easily in children. Therefore, we utilize the serum creatinine (Cr)-based estimated GFR (eGFR) measuring serum Cr by the enzymatic method, and we have reported simple serum Cr-based eGFR in Japanese children aged between 2 and 11?years old. Furthermore, we should use serum Cr-based eGFR in Japanese adolescents as well as children with chronic kidney disease for evaluation of renal function. Methods The inulin clearance and serum Cr level determined by an enzymatic method were measured in 131 pediatric chronic kidney disease (CKD) patients between the ages of 2 and 18?years old with no underlying disease affecting renal function except CKD to determine the serum Cr-based eGFR in Japanese children and adolescents. Results We offer the complex estimated GFR equation using polynomial formulae for reference serum creatinine levels with body length in Japanese children except infants, resulting in the following equation: $$ {\text{eGFR}} = 110.2 \times ({\text{reference serum Cr}}/{\text{patient's serum Cr}}) + 2.93 $$ Reference serum Cr levels (y) are shown by the following two equations of body length (x): $$ \begin{aligned} {\text{Males}}:\quad \, y = & -1.259x^{5} + 7.815x^{4} -18.57x^{3} + 21.39x^{2} -11.71x + 2.628 \\ {\text{Females}}:\quad \, y = & -4.536x^{5} + 27.16x^{4} -63.47x^{3} + 72.43x^{2} -40.06x + 8.778 \\ \end{aligned} $$ Conclusion The new polynomial eGFR formula showing the relationship with body length and serum Cr level may be applicable for clinical screening of renal function in Japanese children and adolescents aged between 2 and 18?years.