Japan Diabetic Nephropathy Cohort Study: study design, methods, and implementation

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• 作者：Kengo Furuichi (1)
  Miho Shimizu (2)
  Tadashi Toyama (2)
  Daisuke Koya (3)
  Yoshitaka Koshino (4)
  Hideharu Abe (5)
  Kiyoshi Mori (6)
  Hiroaki Satoh (7)
  Masahito Imanishi (8)
  Masayuki Iwano (9)
  Hiroyuki Yamauchi (2)
  Eiji Kusano (10)
  Shouichi Fujimoto (11)
  Yoshiki Suzuki (12)
  Seiya Okuda (13)
  Kiyoki Kitagawa (2)
  Yasunori Iwata (2)
  Shuichi Kaneko (2)
  Shinichi Nishi (14)
  Hitoshi Yokoyama (15)
  Yoshihiko Ueda (16)
  Masakazu Haneda (17)
  Hirofumi Makino (18)
  Takashi Wada (19)
  
• 关键词：Diabetic nephropathy ; Cohort study ; Estimated glomerular filtration rate ; Japan Diabetic Nephropathy Cohort Study ; Japan Renal Biopsy Registry ; Japan Kidney Disease Registry
• 刊名：Clinical and Experimental Nephrology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：17
• 期：6
• 页码：819-826
• 全文大小：
• 作者单位：Kengo Furuichi (1)
  Miho Shimizu (2)
  Tadashi Toyama (2)
  Daisuke Koya (3)
  Yoshitaka Koshino (4)
  Hideharu Abe (5)
  Kiyoshi Mori (6)
  Hiroaki Satoh (7)
  Masahito Imanishi (8)
  Masayuki Iwano (9)
  Hiroyuki Yamauchi (2)
  Eiji Kusano (10)
  Shouichi Fujimoto (11)
  Yoshiki Suzuki (12)
  Seiya Okuda (13)
  Kiyoki Kitagawa (2)
  Yasunori Iwata (2)
  Shuichi Kaneko (2)
  Shinichi Nishi (14)
  Hitoshi Yokoyama (15)
  Yoshihiko Ueda (16)
  Masakazu Haneda (17)
  Hirofumi Makino (18)
  Takashi Wada (19)
  
  1. Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan
  2. Department of Disease Control, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
  3. Diabetology and Endocrinology, Kanazawa Medical University School of Medicine, Uchinada, Japan
  4. Mizuho Hospital, Tsubata, Japan
  5. Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
  6. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan
  7. Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Fukushima, Japan
  8. Division of Nephrology and Hypertension, Osaka City General Hospital, Osaka, Japan
  9. Division of Nephrology, Department of General Medicine, University of Fukui, Fukui, Japan
  10. Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan
  11. Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  12. Health Administration Center, Niigata University, Niigata, Japan
  13. Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
  14. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan
  15. Division of Nephrology, Kanazawa Medical University School of Medicine, Uchinada, Japan
  16. Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, Tochigi, Japan
  17. Division of Metabolism and Biosystemic Science, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan
  18. Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  19. Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan
  
• ISSN：1437-7799

文摘

Background Diabetic nephropathy, leading to end-stage renal disease, has a considerable impact on public health and the social economy. However, there are few national registries of diabetic nephropathy in Japan. The aims of this prospective cohort study are to obtain clinical data and urine samples for revising the clinical staging of diabetic nephropathy, and developing new diagnostic markers for early diabetic nephropathy. Methods The Japanese Society of Nephrology established a nationwide, web-based, and prospective registry system. On the system, there are two basic registries; the Japan Renal Biopsy Registry (JRBR), and the Japan Kidney Disease Registry (JKDR). In addition to the two basic registries, we established a new prospective registry to the system; the Japan Diabetic Nephropathy Cohort Study (JDNCS), which collected physical and laboratory data. Results We analyzed the data of 321 participants (106 female, 215 male; average age 65 years) in the JDNCS. Systolic and diastolic blood pressure was 130.1 and 72.3?mmHg, respectively. Median estimated glomerular filtration rate (eGFR) was 33.3?ml/min/1.73?m2. Proteinuria was 1.8?g/gCr, and serum levels of albumin were 3.6?g/dl. The majority of the JDNCS patients presented with preserved eGFR and low albuminuria or low eGFR and advanced proteinuria. In the JRBR and JKDR registries, 484 and 125 participants, respectively, were enrolled as having diabetes mellitus. In comparison with the JRBR and JKDR registries, the JDNCS was characterized by diabetic patients presenting with low proteinuria with moderately preserved eGFR. Conclusions There are few national registries of diabetic nephropathy to evaluate prognosis in Japan. Future analysis of the JDNCS will provide clinical insights into the epidemiology and renal and cardiovascular outcomes of type 2 diabetic patients in Japan.