Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin c: implication in oxidative stress
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- 作者：Toshiyuki Matsunaga ; Yoshitaka Tsuji ; Kairyu Kaai ; Saki Kohno ; Renzo Hirayama ; David H. Alpers ; Tsugikazu Komoda and Akira Hara
- 关键词：Gastric cancer ; 5 ; Fluorouracil ; Mitomycin c ; Reactive oxygen species ; Superoxide dismutase
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2010
- 出版时间：August, 2010
- 年：2010
- 卷：66
- 期：3
- 页码：517-526
- 全文大小：496.6 KB
文摘
Purpose Combined chemotherapy of 5-fluorouracil (5FU) and mitomycin c (MMC) is clinically used for gastric cancer, but the precise conditions and molecular mechanism of these agents when used together remain unclear. We examined the administration sequence of combining 5FU with MMC to maximize toxicity against a human gastric cancer cell line, and then investigated the possible molecular mechanisms underlying the observed toxic effects.