Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and co-infection with hepatitis C Virus

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• 作者：Shimeru Kamihira (1)
  Tetsuya Usui (2)
  Tatsuki Ichikawa (3)
  Naoki Uno (1) (2)
  Yoshitomo Morinaga (1) (2)
  Sayaka Mori (2)
  Kazuhiro Nagai (2)
  Daisuke Sasaki (1) (2)
  Hiroo Hasegawa (1) (2)
  Katsunori Yanagihara (1) (2)
  Takuya Honda (3)
  Yasuaki Yamada (1) (2)
  Masako Iwanaga (4)
  Takashi Kanematu (5)
  Kazuhiko Nakao (3)
  
• 关键词：IL ; 28B ; IL ; 位3 ; HTLV ; 1 ; HCV ; SNP
• 刊名：Virology Journal
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：9
• 期：1
• 全文大小：438KB
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• 作者单位：Shimeru Kamihira (1)
  Tetsuya Usui (2)
  Tatsuki Ichikawa (3)
  Naoki Uno (1) (2)
  Yoshitomo Morinaga (1) (2)
  Sayaka Mori (2)
  Kazuhiro Nagai (2)
  Daisuke Sasaki (1) (2)
  Hiroo Hasegawa (1) (2)
  Katsunori Yanagihara (1) (2)
  Takuya Honda (3)
  Yasuaki Yamada (1) (2)
  Masako Iwanaga (4)
  Takashi Kanematu (5)
  Kazuhiko Nakao (3)
  
  1. Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan
  2. Central Diagnostic Laboratory of Nagasaki University Hospital, Nagasaki, 852-8501, Japan
  3. Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan
  4. Faculty of Wellness Studies, Kwassui Women鈥檚 University, Nagasaki, 850-8515, Japan
  5. Division of Surgical Oncology, Department of Translational Medical Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan
  
• ISSN：1743-422X

文摘

Background Human T-cell leukemia virus type-1 (HTLV-1) carriers co-infected with and hepatitis C virus (HCV) have been known to be at higher risk of their related diseases than mono-infected individuals. The recent studies clarified that IL-28B polymorphism rs8099917 is associated with not only the HCV therapeutic response by IFN, but also innate immunity and antiviral activity. The aim of our research was to clarify study whether IL-28B gene polymorphism (rs8099917) is associated with HTLV-1/HCV co-infection. Results The genotyping and viral-serological analysis for 340 individuals showed that IL-28B genotype distribution of rs8099917 SNP did not differ significantly by respective viral infection status. However, the IL-28B mRNA expression level was 3.8 fold higher in HTLV-1 mono-infection than HTLV-1/HCV co-infection. The high expression level was associated with TT (OR, 6.25), whiles the low expression was associated with co-infection of the two viruses (OR, 9.5). However, there was no association between down-regulation and ATL development (OR, 0.8). Conclusion HTLV-1 mono-infection up-regulates the expression of IL-28B transcripts in genotype-dependent manner, whiles HTLV-1/HCV co-infection down-regulates regardless of ATL development.