Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice
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- 作者：Nobuyuki Nosaka ; Masato Yashiro ; Mutsuko Yamada ; Yosuke Fujii…
- 刊名：Critical Care
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：1
- 全文大小：1,411 KB
- 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
- 出版者：BioMed Central
- ISSN：1364-8535
文摘
Introduction Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the effectiveness of traditional virus-based strategies. This study was undertaken to evaluate the therapeutic effects of anti-high mobility group box-1 (HMGB1) monoclonal antibody (mAb) treatment on influenza A virus (H1N1)-induced pneumonia in mice.