Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division

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• 作者：Zhongyu Shi (1) (2)
  Chunling Xuan (1) (2)
  Huiming Han (1)
  Xia Cheng (1) (3)
  Jundong Wang (3)
  Youjun Feng (4)
  Swaminath Srinivas (5)
  Guangwen Lu (1)
  George F. Gao (1) (2) (6) (7)
  
• 关键词：Streptococcus suis ; Ga5DH ; cell shape ; cell division ; FtsZ localization
• 刊名：Protein & Cell
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：5
• 期：10
• 页码：761-769
• 全文大小：682 KB
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• 作者单位：Zhongyu Shi (1) (2)
  Chunling Xuan (1) (2)
  Huiming Han (1)
  Xia Cheng (1) (3)
  Jundong Wang (3)
  Youjun Feng (4)
  Swaminath Srinivas (5)
  Guangwen Lu (1)
  George F. Gao (1) (2) (6) (7)
  
  1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
  2. University of Chinese Academy of Sciences, Beijing, 100049, China
  3. College of Animal Science and Technology, Shanxi Agricultural University, Taigu, 030801, China
  4. Department of Microbiology, University of Illinois, Urbana, IL, 61801, USA
  5. Department of Biochemistry, University of Illinois, Urbana, IL, 61801, USA
  6. Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China
  7. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China
  
• ISSN：1674-8018

文摘

Bacterial cell division is strictly regulated in the formation of equal daughter cells. This process is governed by a series of spatial and temporal regulators, and several new factors of interest to the field have recently been identified. Here, we report the requirement of gluconate 5-dehydrogenase (Ga5DH) in cell division of the zoonotic pathogen Streptococcus suis. Ga5DH catalyzes the reversible reduction of 5-ketogluconate to D-gluconate and was localized to the site of cell division. The deletion of Ga5DH in S. suis resulted in a plump morphology with aberrant septa joining the progeny. A significant increase was also observed in cell length. These defects were determined to be the consequence of Ga5DH deprivation in S. suis causing FtsZ delocalization. In addition, the interaction of FtsZ with Ga5DH in vitro was confirmed by protein interaction assays. These results indicate that Ga5DH may function to prevent the formation of ectopic Z rings during S. suis cell division.