The Role of Fibrinogen as a Predictor in Preoperative Chemoradiation for Rectal Cancer

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• 作者：Jong Hoon Lee MD (1) (2)
  Jong Hee Hyun MD (1)
  Dae Yong Kim MD (1)
  Byong Chul Yoo PhD (3)
  Ji Won Park MD (1)
  Sun Young Kim MD (1)
  Hee Jin Chang MD (1)
  Byung Chang Kim MD (1)
  Tae Hyun Kim MD (1)
  Jae Hwan Oh MD (1)
  Dae Kyung Sohn MD (1)
  
  1. Center for Colorectal Cancer ; Research Institute and Hospital ; National Cancer Center ; Goyang-si ; Gyeonggi-do ; Republic of Korea
  2. Department of Radiation Oncology ; Seoul St. Mary鈥檚 Hospital ; College of Medicine ; The Catholic University of Korea ; Seoul ; Korea
  3. Colorectal Cancer Branch ; Research Institute ; National Cancer Center ; Goyang-si ; Gyeonggi-do ; Republic of Korea
  
• 刊名：Annals of Surgical Oncology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：22
• 期：1
• 页码：209-215
• 全文大小：187 KB
• 参考文献：1. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. / Lab Invest. 1976;34(3):235-49.
  2. Nand S, Messmore H. Hemostasis in malignancy. / Am J Hematol. 1990;35(1):45鈥?5. CrossRef
  3. Oya M, Akiyama Y, Okuyama T, Ishikawa H. High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer. / Jpn J Clin Oncol. 2001;31(8):388鈥?4. CrossRef
  4. Yamashita H, Kitayama J, Taguri M, Nagawa H. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. / World J Surg. 2009;33(6):1298鈥?05. CrossRef
  5. Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. / Ann Surg Oncol. 2013;20(9):2908鈥?3. CrossRef
  6. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. / N Engl J Med. 2004;351(17):1731鈥?0. CrossRef
  7. Ha YH, Jeong S, Lim S, et al. Influence of preoperative chemoradiotherapy on the number of lymph nodes retrieved in rectal cancer. / Ann Surg. 252(2):336鈥?0. CrossRef
  8. Kim TH, Chang HJ, Kim DY, et al. Pathologic nodal classification is the most discriminating prognostic factor for disease-free survival in rectal cancer patients treated with preoperative chemoradiotherapy and curative resection. / Int J Radiat Oncol Biol Phys. 2010;77(4):1158鈥?5. CrossRef
  9. Kim DY, Jung KH, Kim TH, et al. Comparison of 5-fluorouracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer. / Int J Radiat Oncol Biol Phys. 2007;67(2):378鈥?4. CrossRef
  10. Rdel C, Martus P, Papadoupolos T, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. / J Clin Oncol. 2005;23(34):8688鈥?6. CrossRef
  11. Clauss A. Rapid physiological coagulation method in determination of fibrinogen. / Acta Haematol. 1957;17(4):237-46. CrossRef
  12. Yoon SM, Kim DY, Kim TH, et al. Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer. / Int J Radiat Oncol Biol Phys. 2007;69(4):1167鈥?2. CrossRef
  13. Fu CG, Tominaga O, Nagawa H, et al. Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. / Dis Colon Rectum. 1998;41(1):68鈥?4. CrossRef
  14. Kikuchi M, Mikami T, Sato T, et al. High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction. / Br J Cancer. 2009;101(1):116鈥?3. CrossRef
  15. Park JW, Lim SB, Kim DY, et al. Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery. / Int J Radiat Oncol Biol Phys. 2009;74(3):810鈥?. CrossRef
  16. Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. / Blood. 2000;96(10):3302鈥?.
  17. Camerer E, Qazi A, Duong DN, Cornelissen I, Advincula R, Coughlin SR. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. / Blood. 2004;104(2):397鈥?01. CrossRef
  18. Akakura N, Hoogland C, Takada YK, et al. The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth. / Cancer Res. 2006;66(19):9691鈥?. CrossRef
  19. Kawai K, Kitayama J, Tsuno NH, et al. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. / Int J Colorectal Dis. 2011;26:45鈥?1. CrossRef
  20. Lee NK, Kim DY, Kim SY, et al. Clinical outcomes of local excision following preoperative chemoradiotherapy for locally advanced rectal cancer. / Cancer Res Treatment. 2014;46(2):158鈥?64. CrossRef
  21. Shin A, Kim KZ, Jung KW, et al. Increasing trend of colorectal cancer incidence in Korea, 1999-2009. / Cancer Res Treatment. 2012;44(4):219鈥?6. CrossRef
  22. Wenger RH, Rolfs A, Marti HH, Bauer C, Gassmann M. Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. / J Biol Chem. 1995;270(46):27865鈥?0. CrossRef
  23. Lawrence SO, Simpson-Haidaris PJ. Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation. / Thromb Haemost. 2004;92(2):234鈥?43.
  
• 刊物主题：Surgical Oncology; Oncology; Surgery;
• 出版者：Springer US
• ISSN：1534-4681

文摘

Background To perform chemoradiotherapy (CRT) effectively, it is clinically beneficial to identify predictors of tumor response after CRT. This study examined the association between plasma fibrinogen level before preoperative CRT and tumor response in advanced rectal cancer. Methods This was a retrospective study of 947 patients who received preoperative CRT followed by curative surgery for primary rectal cancer. We analyzed clinical factors that could be associated with pathologic tumor response in terms of downstaging (ypStage 0-I), primary tumor regression (ypT0-1), and complete response (ypT0N0). Results Downstaging was observed in 366 patients (38.6%), primary tumor regression in 187 patients (19.7%) and complete response in 138 patients (14.6%). Multivariate analysis found that pre-CRT carcinoembryonic antigen (CEA) level, fibrinogen level, hemoglobin level, clinical T and N classification, distance from anal verge, and histologic grade were significant predictive factors for downstaging; CEA level, fibrinogen level, and N classification predicted primary tumor regression; CEA level, and fibrinogen level were predictive for complete response. Conclusions This study demonstrated that fibrinogen level was a significant predictor of pathologic tumor response after preoperative CRT.