Aquaporin 2-labeled cells differentiate to intercalated cells in response to potassium depletion

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• 作者：Wan-Young Kim ; Sun Ah Nam ; Arum Choi ; Yu-Mi Kim…
• 关键词：Aquaporin ; Principal cell ; Intercalated cells ; Differentiation
• 刊名：Histochemistry and Cell Biology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：145
• 期：1
• 页码：17-24
• 全文大小：3,978 KB
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• 作者单位：Wan-Young Kim (1)
  Sun Ah Nam (1)
  Arum Choi (1)
  Yu-Mi Kim (1)
  Sang Hee Park (2)
  Yong Kyun Kim (1) (3)
  Jin Kim (1)
  
  1. Department of Anatomy and Cell Death Disease Research Center, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 137-701, Korea
  2. Institute of Clinical Medicine Research of Bucheon St. Mary’s Hospital, Bucheon-si, Korea
  3. Department of Internal Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea, Sosa-ro 327, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-717, Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anatomy
  Medicine/Public Health, general
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-119X

文摘

The mammalian renal collecting duct consists of principal cells (PCs) and intercalated cells (ICs). Both PCs and ICs are involved in potassium (K+) homeostasis, PCs through their role in K+ secretion and ICs through their ability to facilitate K+ resorption. We previously hypothesized that PCs may differentiate into ICs upon K+ depletion. However, no direct evidence has yet been obtained to conclusively demonstrate that PCs differentiate into ICs in response to K+ depletion. Here, we present direct evidence for the differentiation of PCs into ICs by cell lineage tracing using aquaporin 2 (AQP2)-Cre mice and R26R-EYFP transgenic mice. In control mice, AQP2-EYFP+ cells exhibited mainly a PC phenotype (AQP2-positive/H+-ATPase-negative). Interestingly, some AQP2-EYFP+ cells exhibited an IC phenotype (H+-ATPase-positive/AQP2-negative); these cells accounted for 1.7 %. After K+ depletion, the proportion of AQP2-EYFP+ cells with an IC phenotype was increased to 4.1 %. Furthermore, some AQP2-EYFP+ cells exhibited a “null cell” phenotype (AQP2-negative/H+-ATPase-negative) after K+ depletion. Collectively, our data demonstrate that AQP2-labeled cells can differentiate into ICs, as well as null cells, in response to K+ depletion. This finding indicates that some of AQP2-labeled cells possess properties of progenitor cells and that they can differentiate into ICs in the adult mouse kidney.