Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus
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- 作者：Sher-Wei Lim ; Yow-Ling Shiue ; Jen-Chieh Liao ; Hsiao-Yue Wee…
- 关键词：Fluid percussion injury ; Depression ; like behavior ; Forced swim ; Hippocampus ; Maximal angle ; Microglia ; Tumor necrosis factor ; alpha ; Simvastatin
- 刊名：Neurocritical Care
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：26
- 期：1
- 页码：122-132
- 全文大小：
- 刊物主题：Internal Medicine; Neurology; Intensive / Critical Care Medicine;
- 出版者：Springer US
- ISSN：1556-0961
- 卷排序：26
文摘
BackgroundThe antidepressant-like effects of simvastatin on traumatic brain injury (TBI) remain unclear. The present study aimed to investigate the neuroprotective effects of simvastatin and determine whether simvastatin attenuates TBI-induced depression-like behavior and, more specifically, acts as an antineuroinflammatory.