Three new iridoids from the roots of Valeriana jatamansi

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• 作者：Jing Xu (1)
  Yuanqiang Guo (1)
  Da-qing Jin (2)
  Peng Zhao (3)
  Ping Guo (1)
  Tohru Yamakuni (4)
  Yasushi Ohizumi (4)
  
• 关键词：Iridoids ; Valeriana jatamansi ; Valerianaceae
• 刊名：Journal of Natural Medicines
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：66
• 期：4
• 页码：653-657
• 全文大小：290KB
• 参考文献：1. Houghton PJ (1999) The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 51:505-12 CrossRef
  2. Fernández S, Wasowski C, Paladini AC, Marder M (2004) Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from / Valeriana officinalis. Pharmacol Biochem Behav 77:399-04 CrossRef
  3. Ming DS, Yu DQ, Yang YY, He CH (1997) The structures of three novel sesquiterpenoids from / Valeriana jatamansi Jones. Tetrahedron Lett 38:5205-208 CrossRef
  4. Yu LL, Huang R, Han CR, Lv YP, Zhao Y, Chen YG (2005) New iridoid triesters from / Valeriana jatamansi. Helv Chim Acta 88:1059-062 CrossRef
  5. Yu LL, Han CR, Huang R, Lv YP, Gui SH, Chen YG (2006) A new iridoid tetraester from / Valeriana jatamansi. Pharmazie 61:486-88
  6. Lin S, Chen T, Liu XH, Shen YH, Li HL, Shan L, Liu RH, Xu XK, Zhang WD, Wang H (2010) Iridoids and lignans from / Valeriana jatamansi. J Nat Prod 73:632-38 CrossRef
  7. Tang Y, Liu X, Yu B (2002) Iridoids from the rhizomes and roots of / Valeriana jatamansi. J Nat Prod 65:1949-952 CrossRef
  8. Lin S, Shen YH, Li HL, Yang XW, Chen T, Lu LH, Huang ZS, Liu RH, Xu XK, Zhang WD, Wang H (2009) Acylated iridoids with cytotoxicity from / Valeriana jatamansi. J Nat Prod 72:650-55 CrossRef
  9. Guo P, Li Y, Xu J, Liu C, Ma Y, Guo Y (2011) Bioactive / neo-clerodane diterpenoids from the whole plants of / Ajuga ciliata Bunge. J Nat Prod 74:1575-583 CrossRef
  10. Xu J, Zhang P, Ma Z, Guo Y, Zhao X, Wei K (2009) Two carabrane-type sesquiterpenes from / Vladimiria souliei. Phytochem Lett 2:204-06 CrossRef
  11. Xu J, Zhao P, Guo Y, Xie C, Jin DQ, Ma Y, Hou W, Zhang T (2011) Iridoids from the roots of / Valeriana jatamansi and their neuroprotective effects. Fitoterapia 82:1133-136 CrossRef
  12. Lin S, Shen YH, Zhang ZX, Li HL, Shan L, Liu RH, Xu XK, Zhang WD (2010) Revision of the structures of 1,5-dihydroxy-3,8-epoxyvalechlorine, volvaltrate B, and valeriotetrate C from / Valeriana jatamansi and / V. officinalis. J Nat Prod 73:1723-726 CrossRef
  
• 作者单位：Jing Xu (1)
  Yuanqiang Guo (1)
  Da-qing Jin (2)
  Peng Zhao (3)
  Ping Guo (1)
  Tohru Yamakuni (4)
  Yasushi Ohizumi (4)
  
  1. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300071, China
  2. School of Medicine, Nankai University, Tianjin, 300071, China
  3. Tianjin Children’s Hospital, Tianjin, 300074, China
  4. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan
  
• ISSN：1861-0293

文摘

Three new iridoids, valeriandoids D–F (1-strong class="a-plus-plus">3), have been isolated from the roots of Valeriana jatamansi. Structure elucidation, especially the positions of the acyloxy groups, and complete 1H- and 13C-NMR assignments of these new compounds were carried out using one- and two-dimensional NMR measurements, including 1H- and 13C-NMR, DEPT-135, 1H-sup class="a-plus-plus">1H COSY, HMQC, HMBC, and HR-ESI-MS experiments.