ASIC subunit ratio and differential surface trafficking in the brain

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• 作者：Junjun Wu ; Yuanyuan Xu ; Yu-Qing Jiang ; Jiangping Xu ; Youjia Hu…
• 关键词：ASIC ; Subunit ratio ; Stoichiometry ; Surface expression
• 刊名：Molecular Brain
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：2,151 KB
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• 作者单位：Junjun Wu (1) (2)
  Yuanyuan Xu (1) (3)
  Yu-Qing Jiang (1) (4)
  Jiangping Xu (3)
  Youjia Hu (2)
  Xiang-ming Zha (1)
  
  1. Department of Physiology and Cell Biology, University of South Alabama College of Medicine, 5851 USA Dr N, MSB3074, Mobile, AL, 36688, USA
  2. China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai, 201203, China
  3. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
  4. Department of Urology, The Third Hospital of Hebei Medical University, Shijiazhuang, HeBei, China
  
• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：1756-6606

文摘

Background Acid-sensing ion channels (ASICs) are key mediators of acidosis-induced responses in neurons. However, little is known about the relative abundance of different ASIC subunits in the brain. Such data are fundamental for interpreting the relative contribution of ASIC1a homomers and 1a/2 heteromers to acid signaling, and essential for designing therapeutic interventions to target these channels. We used a simple biochemical approach and semi-quantitatively determined the molar ratio of ASIC1a and 2 subunits in mouse brain. Further, we investigated differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b.