Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance

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• 作者：Yuanyuan Zhang (1)
  Junming Guo (1)
  Dong Li (1)
  Bingxiu Xiao (1)
  Ying Miao (1) (2)
  Zhen Jiang (1)
  Hui Zhuo (1)
  
• 关键词：MicroRNA ; 31 ; Gastric cancer ; Gene expression ; Gene diagnosis
• 刊名：Medical Oncology
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：27
• 期：3
• 页码：685-689
• 全文大小：204KB
• 参考文献：1. Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 1999;83:18鈥?9. CrossRef
  2. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990鈥?020: global burden of disease study. Lancet. 1997;349:1498鈥?04. CrossRef
  3. Gaspar MJ, Arribas I, Coca MC, Diez-Alonso M. Prognostic value of carcinoembryonic antigen, CA 19-9 and CA 72-4 in gastric carcinoma. Tumour Biol. 2001;22:318鈥?2. CrossRef
  4. Marrelli D, et al. Prognostic significance of CEA, CA 19-9 and CA 72-4 preoperative serum levels in gastric carcinoma. Oncology. 1999;57:55鈥?2. CrossRef
  5. Carpelan-Holmstrom M, Louhimo J, Stenman UH, Alfthan H, Haglund C. CEA, CA 19-9 and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers. Anticancer Res. 2002;22:2311鈥?.
  6. Takahashi Y, et al. The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study. Gastric Cancer. 2003;6:142鈥?. CrossRef
  7. Hatfield S, Ruohola-Baker H. microRNA and stem cell function. Cell Tissue Res. 2008;331:57鈥?6. CrossRef
  8. Calin GA, Croce CM. MicroRNA-cancer connection: 鈥榯he beginning of a new tale鈥? Cancer Res. 2006;66:7390鈥?. CrossRef
  9. Volinia S, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 2006;103:2257鈥?1. CrossRef
  10. Bandr茅s E, et al. Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer. 2006;5:29. CrossRef
  11. Chan SH, Wu CW, Li AF, Chi CW, Lin WC. miR-21 microRNA expression in human gastric carcinomas and its clinical association. Anticancer Res. 2008;28:907鈥?1.
  12. Zhang HH, Wang XJ, Li GX, Yang E, Yang NM. Detection of let-7a microRNA by real-time PCR in gastric carcinoma. World J Gastroenterol. 2007;13:2883鈥?. CrossRef
  13. Ji Q, et al. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer. 2008;8:266. CrossRef
  14. Guo J, et al. Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 2009;24:652鈥?. CrossRef
  15. Sobin LH, Wittekind CH, editors. TNM classification of malignant tumors 5th edition, International Union Against Cancer (UICC). New York: Wiley; 1997. p. 59鈥?2.
  16. Solcia E, et al. Endocrine tumours of the gastrointestinal tract. In: Solcia E, Kl枚ppel G, Sobin LH, editors. Histological typing of endocrine tumours. 2nd ed. Berlin: Springer-Verlag; 2000. p. 61鈥?.
  17. Lawrie CH, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008;141:672鈥?. CrossRef
  18. Peng JJ, et al. Predicting prognosis of rectal cancer patients with total mesorectal excision using molecular markers. World J Gastroenterol. 2007;13:3009鈥?5.
  19. Wang SL, et al. Increased expression of hLRH-1 in human gastric cancer and its implication in tumorigenesis. Mol Cell Biochem. 2008;308:93鈥?00. CrossRef
  20. Yan LX, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA. 2008;14:2348鈥?0. CrossRef
  21. Shen J, et al. MicroRNAs regulate ocular neovascularization. Mol Ther. 2008;16:1208鈥?6. CrossRef
  22. Guglielmelli P, et al. MicroRNA expression profile in granulocytes from primary myelofibrosis patients. Exp Hematol. 2007;35:1708鈥?8. CrossRef
  23. Wong QW, et al. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology. 2008;135:257鈥?9. CrossRef
  24. Wong TS, et al. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res. 2008;14:2588鈥?2. CrossRef
  
• 作者单位：Yuanyuan Zhang (1)
  Junming Guo (1)
  Dong Li (1)
  Bingxiu Xiao (1)
  Ying Miao (1) (2)
  Zhen Jiang (1)
  Hui Zhuo (1)
  
  1. Ningbo University School of Medicine, 315211, Ningbo, China
  2. Affiliated Hospital (Ningbo No. 2 Hospital), Ningbo University School of Medicine, 315010, Ningbo, China
  

文摘

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.