Molecular epidemiology and population dynamics of hepatitis B virus in Dianjiang County, Chongqing, China
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- 作者：Mingyan Ma (1)
Miao He (2)
Liya Liao (1)
Yuanyuan Guo (3)
Dengqiong Yu (1)
Zhongzheng Xiong (1)
Yu Liu (2)
Peibin Zeng (2)
Pu Liao (3) - 刊名：Archives of Virology
- 出版年：2014
- 出版时间：January 2014
- 年：2014
- 卷：159
- 期：1
- 页码：117-124
- 全文大小：334 KB
- 作者单位：Mingyan Ma (1)
Miao He (2)
Liya Liao (1)
Yuanyuan Guo (3)
Dengqiong Yu (1)
Zhongzheng Xiong (1)
Yu Liu (2)
Peibin Zeng (2)
Pu Liao (3)
1. Dianjiang people’s hospital of Chongqing, Chongqing, China
2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Beijing, China
3. The Third People’s Hospital of Chongqing, Chongqing, China - ISSN：1432-8798
文摘
Hepatitis B virus infection is highly endemic in China, especially in rural areas such as Dianjiang County with poor-quality health care and little local HBV information. Therefore, for the first time, the present study was carried out to investigate the molecular epidemiology, phylogeny and population dynamics of HBV based on 146 HBV-infected patients. A 435-bp portion of the HBV S region was sequenced, and the phylogeny was reconstructed, indicating that three genotypes, B, C and D of HBV were distributed in Dianjiang County. The predominant genotype is B (67.12?%), followed by C (32.19?%) and D (0.68?%). Patient demographic information and clinical outcomes were examined by genotypes, and no significant association was found. Population dynamics analysis suggested that both genotype B and C have experienced a tenfold expansion during the last five years for reasons that are unclear. Thus, a thorough molecular epidemiology investigation is strongly recommended in the future.