P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case¨Ccontrol studies

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• 作者：Zhizhong Zhang ; Meilin Wang ; Dongmei Wu ; Miaomiao Wang ; Na Tong ; Yuanyuan Tian and Zhengdong Zhang
• 关键词：P53 ; Breast cancer ; Meta ; analysis ; Molecular epidemiology ; Genetic variation
• 刊名：Breast Cancer Research and Treatment
• 出版年：2010
• 出版时间：April, 2010
• 年：2010
• 卷：120
• 期：2
• 页码：509-517
• 全文大小：281.2 KB

文摘

P53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies revealing conflicting results on the role of p53 codon 72 polymorphism (G>C) on breast cancer risk led us to perform a meta-analysis to investigate this relationship. Thirty-nine published studies, including 26,041 breast cancer cases and 29,679 controls were identified. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. The overall results suggested that the variant genotypes were associated with a significantly reduced breast cancer risk (GC vs. GG: OR = 0.91, 95 % CI: 0.83–1.00; CC/GC vs. GG: OR = 0.90, 95 % CI: 0.82–0.99). In the stratified analyses, significantly decreased risks were also found among European populations (GC vs. GG: OR = 0.89, 95 % CI: 0.80–0.99; CC/GC vs. GG: OR = 0.88, 95 % CI: 0.80–0.98) and studies with population-based controls (GC vs. GG: OR = 0.88, 95 % CI: 0.78–0.98; CC/GC vs. GG: OR = 0.87, 95 % CI: 0.78–0.97). The results suggested that p53 codon 72 polymorphism may contribute to susceptibility to breast cancer, especially in Europeans. Additional well-designed large studies were required to validate this association in different populations.