BTG3 upregulation induces cell apoptosis and suppresses invasion in esophageal adenocarcinoma

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• 作者：Yuwen Du ; Pingping Liu ; Wenqiao Zang ; Yuanyuan Wang…
• 关键词：Esophageal adenocarcinoma ; BTG3 ; Proliferation ; Migration
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：404
• 期：1-2
• 页码：31-38
• 全文大小：1,672 KB
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• 作者单位：Yuwen Du (1)
  Pingping Liu (1)
  Wenqiao Zang (1)
  Yuanyuan Wang (1)
  Xiaonan Chen (1)
  Min Li (1)
  Guoqiang Zhao (1)
  
  1. College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, Zhengzhou, 450001, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Medical Biochemistry
  Oncology
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4919

文摘

B cell translocation gene 3 (BTG3) is a tumor suppressor by inhibiting cell proliferation, migration, and regulating cell cycle progression in several tumors. However, its role in esophageal adenocarcinoma (EAC) remains unknown. Here, we detected the expression of BTG3 in EAC tissues and subsequent progression. BTG3 expression was significant decreased in EAC tissues and cell lines detected by real-time RT–PCR and Western blot. Relationships of BTG3 with EAC clinicopathology were analyzed statistically. The decrease expression of BTG3 is associated with lymph node metastases. In vitro assay demonstrated that overexpression of BTG3 significantly suppressed colony formation and proliferation of EAC cells. The suppressed migration and invasion abilities found in BTG3-overexpressing EAC cells. Our findings suggested that BTG3 is suppressor in the progression of EAC.